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MetabolomicsUntargeted Metabolomics To Ascertain Antibiotic Modes of Action
Deciphering the mode of action (MOA) of new antibiotics discovered through phenotypic screening is of increasing importance. Metabolomics offers a potentially rapid and cost-effective means of identifying modes of action of drugs whose effects are mediated through changes in metabolism. Metabolomics...
2017-06-16 | MTBLS464 | MetaboLights
MetabolomicsDetermination of mode of action of anti-malalrial drugs using untargeted metabolomics
Not available
ORGANISM(S): Plasmodium falciparum 
ST001033 | MetabolomicsWorkbench
MetabolomicsMetabolomic analysis of the mechanism of action of yerba mate extract on Salmonella Typhimurium
Background: Salmonella Typhimurium is a gram-negative enteropathogen that infects millions worldwide; the rapid emergence of antibiotic resistant strains has heightened the urgency of developing effective treatment for this pathogen. Previous studies have demonstrated that the aqueous extract of yer...
2017-02-16 | MTBLS359 | MetaboLights
MetabolomicsMetabolomics-based profiling of the mode of action of Pathogen Box compounds in Trypanosoma brucei (part-I)
Not available
ORGANISM(S): Trypanosoma brucei brucei 
ST001274 | MetabolomicsWorkbench
MetabolomicsMetabolomics-based profiling of the mode of action of Pathogen Box compounds in Trypanosoma brucei (part-II)
Not available
ORGANISM(S): Trypanosoma brucei brucei 
ST001275 | MetabolomicsWorkbench
MetabolomicsAnalyzing nicotine action against amyloid toxicity by NMR-pharmacometabolomics: an exploratory study

Alzheimer's disease (AD) is the primary neurodegenerative disease spread worldwide. One of the main histopathological hallmarks of AD is amyloid plaque deposition in the brain. Despite some epidemiological studies demonstrating that cigarette smoke is a factor in predisposing people to AD, nicoti...

2026-06-26 | MTBLS12706 | MetaboLights
MetabolomicsMulti-omics analysis demonstrates unique mode of action of a potent new antimalarial compound, JPC-3210, against Plasmodium falciparum
Not available
ORGANISM(S): Plasmodium falciparum 
ST001175 | MetabolomicsWorkbench
TranscriptomicsCharacterization of Formaldehyde's Genotoxic Mode of Action by Gene Expression Analysis in TK6 Cells
Gene expression analysis has been established as a tool for the characterization of genotoxic mechanisms of chemical mutagens. This approach has been shown to differentiate between DNA reactive genotoxins and non-DNA reactive or indirectly-acting genotoxins. In this context, it has been suggested th...
ORGANISM(S): Homo sapiens 
2013-05-13 | E-GEOD-41296 | biostudies-arrayexpress
MetabolomicsMechanisms of action of bile acids in pediatric gastroesophageal reflux: Exploration through non-targeted and targeted metabolomics methods

Purpose: To investigate the pathogenesis of pediatric bile reflux gastritis (BRG) using non-targeted and targeted metabolomics analyses of the changes and content differences of bile acids (BAs) in gastric juice. Methods: Data from 25 pediatric BRG patients treated at Jinhua Maternal and Child He...

2025-12-04 | MTBLS13450 | MetaboLights
GenomicsPraziquantel mode of action and resistance
Praziquantel mode of action and resistance
PRJEB1281 | ENA
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