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TranscriptomicsDifferences in platelet miRNA profiles between patients with coronary artery disease and healthy controls.
Coronary artery disease (CAD) is the leading cause of human morbidity and mortality worldwide, underscoring the need to improve diagnostic strategies. Platelets play a major role, not only in the process of acute thrombosis during plaque rupture, but also in the formation of atherosclerosis itself. ...
ORGANISM(S): Homo sapiens 
2015-06-22 | E-GEOD-59421 | biostudies-arrayexpress
TranscriptomicsLow-power photodynamic therapy induces survival signaling in cultured hilar cholangiocarcinoma cells
Photodynamic therapy (PDT) of solid cancers comprises the administration of a photosensitizer followed by illumination of the photosensitizerreplete tumor with laser light. This induces a state of local oxidative stress, culminating in the destruction of tumor tissue and microvasculature and inducti...
ORGANISM(S): Homo sapiens 
2016-01-04 | E-GEOD-68292 | biostudies-arrayexpress
TranscriptomicsInterorgan coordination of the murine adaptive response to fasting
The effects of fasting have been studied extensively, predominantly on isolated processes, within a specific organ. No comprehensive study of the adaptations was available for different organs, let alone interrelating them, which left the understanding of the body’s orchestration of fasting response...
ORGANISM(S): Mus musculus 
2011-03-09 | E-GEOD-24504 | biostudies-arrayexpress
TranscriptomicsMolecular profiling of cytomegalovirus-induced human CD8+ T cell differentiation
CD8+ T cells play a critical role in the immune response to viral pathogens. Persistent human CMV (HCMV) infection results in a strong increase in the number of virus-specific, quiescent effector-type CD8+ T cells with constitutive cytolytic activity, but the molecular pathways involved in the ind...
ORGANISM(S): Homo sapiens 
2010-09-15 | E-GEOD-24151 | biostudies-arrayexpress
TranscriptomicsThe transcriptional profile of human CD8+ lung resident memory T-cells
A specialized population of memory CD8+ T-cells resides in the epithelium of the respiratory tract to maintain protection against recurring infections. These cells express CD69 and the integrin αβ7 (CD103) and correspond to tissue resident memory T-cells (TRM) also described in intestine, liver an...
ORGANISM(S): Homo sapiens 
2016-10-23 | E-GEOD-61397 | biostudies-arrayexpress
TranscriptomicsInvolvement of the TGF-β and β-catenin pathways in pelvic lymph node metastasis in early stage cervical cancer
Purpose: Presence of pelvic lymph node metastases is the main prognostic factor in early stage cervical cancer patients, primarily treated with surgery. Aim of this study was to identify cellular tumor pathways associated with pelvic lymph node metastasis in early stage cervical cancer. Experimental...
ORGANISM(S): Homo sapiens 
2011-02-15 | E-GEOD-26511 | biostudies-arrayexpress
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