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Kindlin-2/Moesin interaction orchestrates sprouting angiogenesis via modulating endothelial membrane mechanics and VEGF signaling
Membrane mechanics play a crucial role in cellular signaling and fate determination, yet their impact on angiogenesis remains poorly understood. Here, we identify Kindlin-2 as a key regulator of sprouting angiogenesis via regulating endothelial membrane tension through its interaction with Moesin, a...
ORGANISM(S): Homo sapiens 
2025-07-23 | GSE302986 | GEO
THE ACTIN-BINDING MOESIN PROTEIN IS REQUIRED FOR HEAT SHOCK GENE EXPRESSION IN DROSOPHILA
Genome-wide association studies (GWAS) implicated a noncoding antisense RNA designated as MSNP1AS in susceptibility to autism spectrum disorders (ASD). MSNP1AS binds to and downregulates the Moesin (MSN) transcript and is highly overexpressed in postmortem cerebral cortex of individuals with ASDs. H...
ORGANISM(S): Mus musculus 
2025-06-11 | GSE293405 | GEO
The cytoskeletal actin-binding ERM (ezrin, radixin and moesin) proteins play essential role in modulating numerous signal transduction events in the cytoplasm by crosslinking actin filaments with plasma membrane proteins. The nuclear localization of ERMs has been also reported and the involvement of...
ORGANISM(S): Drosophila melanogaster 
2020-08-06 | GSE155778 | GEO
Moesin deficiency leads to microglia-mediated synaptic pruning and social abnormality: a post-GWAS functional genomics study
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