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ProteomicsSecretome of trophoblast organoids
Characterisation of the secretome of placental organoids using Liquid Chromatography and Mass Spectrometry by performing solid phase extraction of the supernatants, followed by tryptic digestion.
ORGANISM(S): Homo sapiens (Human) 
2018-11-29 | PXD009118 | Pride
Secretion Lc-ms Trophoblast organoids Solid phase extraction 
TranscriptomicsSharkey trophoblast
Transcriptional profiling comparison of human primary villous trophoblast and extra-villous trophoblast (VT and EVT respectively) cells, isolated from the placenta at 8 to 12 weeks gestation, with complimentary transcriptional profiling of choriocarcinoma cell lines JEG-3 and JAR. Based on phenotypi...
ORGANISM(S): Homo sapiens 
2011-04-28 | E-MTAB-429 | biostudies-arrayexpress
TranscriptomicsDecidual NK cells Xiong et al 2013
Receptors of the KIR family on maternal Natural Killer cells in the decidua are believed to bind to Ligands such as HLA-C on trophoblast cells invading into the decidua from the placenta during early pregnancy. The resulting responses regulate the extent of trophoblast invasion. Genetic studies have...
ORGANISM(S): Homo sapiens 
2014-04-04 | E-MTAB-1784 | biostudies-arrayexpress
TranscriptomicsHuman uterine Natural Killer cells regulate differentiation of extravillous trophoblast early in pregnancy - scRNA-seq data
We used trophoblast organoids differentiating to extravillous trophoblast (EVT) to study the effects of key cytokines secreted by uterine Natural Killer (uNK) cells on EVT behaviour. Specifically, we exposed the organoids to four uNK-derived cytokines (CSF1, CSF2, XCL1, CCL5) and collected cells at ...
ORGANISM(S): Homo sapiens 
2024-01-10 | E-MTAB-13382 | biostudies-arrayexpress
TranscriptomicsHuman uterine Natural Killer cells regulate differentiation of extravillous trophoblast early in pregnancy - bulk RNA-seq data
An allorecognition system depending on interactions between uterine Natural Killer (uNK) cells and placental extravillous trophoblast (EVT) during early pregnancy influences reproductive outcomes in humans. Our previous immunogenetic studies show that particular combinations of maternal Killer Immun...
ORGANISM(S): Homo sapiens 
2024-01-10 | E-MTAB-13379 | biostudies-arrayexpress
TranscriptomicsTranscriptional characterization of primary human HLA-G+ extravillous trophoblasts (EVT) and Villous trophoblasts (VT)
Seven patient paired primary human HLA-G+ extravillous trophoblasts (EVT) and Villous trophoblasts (VT) obtained from 1st trimester (7-9 weeks) villous tissue were obtained. RNA was isolated directly after isolation and purification using FACS sort for CD45-HLA-G+ (EVT) and CD45-HLA-G-EGFR1+ (VT) fr...
ORGANISM(S): Homo sapiens 
2015-05-15 | E-MTAB-3217 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-seq of Endometrial organoids treated with NOTCH or WNT inhibitors in a time course of Estrogen and Progesterone stimulation
We performed single-cell RNA-sequencing of 3D endometrial organoid cultures in order to dissect the signaling pathways that determine cell fate of epithelial lineages. Every time course was obtained in a background that either included or did not include ovarian hormones stimulation, which emulates ...
ORGANISM(S): Homo sapiens 
2021-07-21 | E-MTAB-10283 | biostudies-arrayexpress
TranscriptomicsEvidence for widespread changes in promoter methylation profile in human placenta in response to increasing gestational age and environmental/stochastic factors.
Background: the human placenta facilitates the exchange of nutrients, gas and waste between the fetal and maternal circulations. It also protects the fetus from the maternal immune response. Due to its role at the feto-maternal interface, the placenta is subject to many environmental exposures that ...
ORGANISM(S): Homo sapiens 
2011-08-31 | E-GEOD-31781 | biostudies-arrayexpress
TranscriptomicsWide ranging DNA methylation differences of primary trophoblast cell populations and derived-cell lines
Difficulties associated with long term culture of primary trophoblasts have proven to be a major hurdle in their functional characterization. In order to circumvent this issue, several model cell lines have been established over many years using a variety of different approaches. Due to their differ...
ORGANISM(S): Homo sapiens 
2011-01-20 | E-GEOD-26683 | biostudies-arrayexpress
TranscriptomicsTranscriptomic profile of human placenta derived trophoblast organoid cultures with its tissue of origin, human placental villi.
The aim of this microarray experiment was to compare the overall transcriptomic profile of human placenta derived trophoblast organoid cultures with its tissue of origin, human placental villi. As the placental villi contains both trophoblast and stromal populations, we have included placenta derive...
ORGANISM(S): Homo sapiens 
2018-11-28 | E-MTAB-6683 | biostudies-arrayexpress
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