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UnknownSynthesis and in Silico Investigation of Organoselenium-Clubbed Schiff Bases as Potential Mpro Inhibitors for the SARS-CoV-2 Replication.
Not available
S-EPMC10141725 | biostudies-literature
UnknownIn Silico Development of Novel Benzofuran-1,3,4-Oxadiazoles as Lead Inhibitors of M. tuberculosis Polyketide Synthase 13.
Not available
S-EPMC10303075 | biostudies-literature
TranscriptomicsControl cDNA microarray profiles of Drosophila head
In the process of developing a biological systems model of kindling-like plasticity in the fruit fly, we performed a control gene expression profiling analysis in which RNA isolated from different pools of heads of wild-type flies grown on normal food (NF) were compared between themselves using cDNA...
ORGANISM(S): Drosophila melanogaster 
2007-10-01 | E-GEOD-7037 | biostudies-arrayexpress
UnknownA stability-illustrating HPLC-DAD method for assessment of two veterinary anti-parasitic drugs: appraisal of the method's greenness and blueness.
Not available
S-EPMC11823049 | biostudies-literature
TranscriptomicsChronic Pentylenetetrazol treatment induced successive gene expression changes in Drosophila head
Pentylenetetrazol (PTZ)-induced kindling in rodents is an established model of epileptogenesis. The molecular basis of the associated long-term plasticity is however not clear. Further, rodent models of kindling plasticity are not amenable to large-scale screening of compounds for identifying antiep...
ORGANISM(S): Drosophila melanogaster 
2007-10-01 | E-GEOD-7120 | biostudies-arrayexpress
MetabolomicsHypusination Orchestrates the Antimicrobial Response of Macrophages
Innate responses of myeloid cells defend against pathogenic bacteria via inducible effectors. Deoxyhypusine synthase (DHPS) catalyzes the transfer of the N-moiety of spermidine to the lysine-50 residue of eukaryotic translation initiation factor 5A (EIF5A) to form the amino acid hypusine. Hypusinate...
2021-04-06 | MTBLS607 | MetaboLights
MetabolomicsCTH exacerbates Helicobacter pylori immunopathogenesis by promoting macrophage metabolic remodeling and activation
Macrophages play a crucial role in the inflammatory response to the human stomach pathogen Helicobacter pylori, which infects half of the world's population and causes gastric cancer. Recent studies have highlighted the importance of macrophage immunometabolism in their activation state and function...
2022-06-14 | MTBLS2851 | MetaboLights
TranscriptomicsCytotoxic and anti-Toxoplasma gondii activities of monensin on human brain microvascular endothelial cells
The aim of the present work was to investigate the effect of monensin on the in vitro growth of T. gondii tachyzoites and on the host cells (human brain microvascular endothelial cells - hBMECs). The hypotheses were that (1) inhibition of the WNT signalling pathway by monensin can reduce the growth ...
ORGANISM(S): Homo sapiens 
2020-07-06 | E-MTAB-8817 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human tetracycline-regulated cell line expressing an NF-kB inhibitor to systematically identify NF-kB dependent genes
TNF time course series of HelA tet off cells cultured in presence or absence of Dox; TNF is a pro-inflammatory cytokine that controls expression of inflammatory genetic networks. Although the Nuclear Factor-kB (NF-kB) pathway is crucial for mediating cellular TNF responses, the complete spectrum of...
ORGANISM(S): Homo sapiens 
2007-09-07 | E-GEOD-2624 | biostudies-arrayexpress
UnknownDFT, ADMET and Molecular Docking Investigations for the Antimicrobial Activity of 6,6'-Diamino-1,1',3,3'-tetramethyl-5,5'-(4-chlorobenzylidene)bis[pyrimidine-2,4(1H,3H)-dione].
Not available
S-EPMC8839838 | biostudies-literature
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