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TranscriptomicsStructural polymorphism in the promoter of pfmrp2 confers tolerance to mefloquine and chloroquine in Plasmodium falciparum [expression]
Drug resistance in Plasmodium falciparum remains a challenge for the malaria eradication programs around the world. With the emergence of artemisinin resistance, the efficacy of the partner drugs in the artemisinin combination therapies (ACT) that include quinoline based drugs is becoming critical. ...
ORGANISM(S): Plasmodium falciparum 
2013-02-07 | E-GEOD-44127 | biostudies-arrayexpress
TranscriptomicsStructural polymorphism in the promoter of pfmrp2 confers tolerance to mefloquine and chloroquine in Plasmodium falciparum.
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Plasmodium falciparum 
2013-02-07 | E-GEOD-44129 | biostudies-arrayexpress
TranscriptomicsStructural polymorphism in the promoter of pfmrp2 confers tolerance to mefloquine and chloroquine in Plasmodium falciparum [CGH]
Drug resistance in Plasmodium falciparum remains a challenge for the malaria eradication programs around the world. With the emergence of artemisinin resistance, the efficacy of the partner drugs in the artemisinin combination therapies (ACT) that include quinoline based drugs is becoming critical. ...
ORGANISM(S): Plasmodium falciparum 
2013-02-07 | E-GEOD-44128 | biostudies-arrayexpress
TranscriptomicsWhole genome expression profiling of artemsinin-resistant Plasmodium falciparum field isolates [in vivo]
The objective of our study is to characterize gene expression signatures associated with in vivo artemisinin-resistance phenotype in this large-scale genome-wide association study. To achieve this goal, we employed microarray technology to establish the global gene expression profiles of isolates sa...
ORGANISM(S): Plasmodium falciparum 
2014-07-15 | E-GEOD-59097 | biostudies-arrayexpress
TranscriptomicsPlasmodium knowlesi gene expression differs in ex vivo compared to in vitro blood-stage cultures
The purpose of this reasearch is to identify and evaluate the global gene expression of Plasmodium knowlesi blood-stage parasites and specifically compare the gene expression profiles of samples derived from ex vivo versus long-term in vitro cultures. For ex vivo samples, a rhesus monkey was infecte...
ORGANISM(S): Plasmodium knowlesi 
2015-06-08 | E-GEOD-62886 | biostudies-arrayexpress
ProteomicsGlobal protein quantification of changes in K13 mutant and isogenic wild-type P. falciparum parasites during the intra-erythrocytic developmental cycle
K13 mutations are causal for artemisinin resistance in Plasmodium falciparum human malaria. We characterized changes in protein abundance associated with K13 mutations during the parasite's 48h intra-erythrocytic developmental cycle by comparing protein expression profiles of K13 mutant (C580Y, R539...
ORGANISM(S): Plasmodium falciparum 
2020-11-23 | PXD019612 | Pride
Plasmodium falciparum K13 Proteomics Malaria Artemisinin resistance 
TranscriptomicsTranscriptional profiling of growth perturbations of the human malaria parasite Plasmodium falciparum
The microarray experiments were carried out using a long oligonucleotide DNA microarray that represent all 5363 P. falciparum genes with one oligonucleotide per 1.9kb of coding sequence on average (Hu et al. 2007). Total 247 microarray experiments were carried out including 29-drug treatment time co...
ORGANISM(S): Plasmodium falciparum 
2010-05-18 | E-GEOD-19468 | biostudies-arrayexpress
TranscriptomicsComparison of relative transcript and protein abundance in Plasmodium falciparum schizont stage parasites
Background: Malaria is a one of the most important infectious diseases and is caused by parasitic protozoa of the genus Plasmodium. Previously, the quantitative characterization of the P. falciparum transcriptome demonstrated that the strictly controlled progression of these parasites through their ...
ORGANISM(S): Plasmodium falciparum 
2010-05-05 | E-GEOD-13251 | biostudies-arrayexpress
TranscriptomicsNew insights into the Plasmodium vivax transcriptome using RNA-seq
Transcription profile of the Plasmodium vivax intraerythrocytic cycle Total RNA in Plasmodium vivax strain at every 6 hour of intraerythrocytic cycle using RNA-seq
ORGANISM(S): Plasmodium vivax 
2016-02-11 | E-GEOD-61252 | biostudies-arrayexpress
TranscriptomicsWhole transcriptome analysis of rosetting Plasmodium falciparum parasites
Background: The cytoadherence of Plasmodium falciparum is thought to be mediated by variant surface antigens (VSA), encoded by var, rif, stevor and pfmc-2tm genes. The last three families have rarely been studied in the context of cytoadherence. As most VSA genes are unique, the variability among s...
ORGANISM(S): Plasmodium falciparum 
2011-07-01 | E-GEOD-28990 | biostudies-arrayexpress
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