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MetabolomicsFour layer multi-omics reveals molecular responses to aneuploidy in Leishmania

Aneuploidy causes system-wide disruptions in the stochiometric balances of transcripts, proteins, and metabolites, often resulting in detrimental effects for the organism. The protozoan parasite Leishmania has an unusually high tolerance for aneuploidy, but the molecular and functional consequenc...

2022-09-19 | MTBLS1612 | MetaboLights
ModelsProctor2005 - Actions of chaperones and their role in ageing
Proctor2005 - Actions of chaperones and their role in ageing This model is described in the article: Modelling the actions of chaperones and their role in ageing. Proctor CJ, Soti C, Boys RJ, Gillespie CS, Shanley DP, Wilkinson DJ, Kirkwood TB. Mech. Ageing Dev. 2005 Jan; 126(...
2024-09-02 | BIOMD0000000091 | BioModels
ProteomicsSmall heat shock proteins operate as molecular chaperones in the mitochondrial intermembrane space
Mitochondria are complex organelles with different compartments, each harboring their own protein quality control factors. While the chaperones of the mitochondrial matrix have been well characterized, it is poorly understood which chaperones protect the mitochondrial intermembrane space. We show th...
ORGANISM(S): Homo sapiens (Human) 
2022-12-12 | PXD038275 | Pride
Charcot-marie-tooth (cmt) disease Protein quality control Intermembrane space Small heat shock proteins Mitochondria Chaperones 
ProteomicsThe landscape of molecular chaperones across human tissues reveals a layered architecture of core-variable chaperones
The sensitivity of the protein-folding environment to chaperone disruption can be highly tissue-specific. Yet, the organization of the chaperone system across physiological human tissues has received little attention. Through computational analyses of large-scale tissue transcriptomes, we unveiled t...
ORGANISM(S): Mus musculus (Mouse) 
2021-02-08 | PXD022678 | Pride
Chaperones  aging  data integration  differentiation  protein quality control  protein misfolding diseases  proteostasis  systems biology  tissue specificity compression networks 
UnknownMolecular chaperones and photoreceptor function.
Not available
S-EPMC2568879 | biostudies-literature
UnknownInduction of molecular chaperones in carbon tetrachloride-treated rat liver: implications in protection against liver damage.
Not available
S-EPMC1065307 | biostudies-literature
GenomicsDNAJC9 Integrates Heat Shock Molecular Chaperones into the Histone Chaperone Network
DNAJC9 Integrates Heat Shock Molecular Chaperones into the Histone Chaperone Network
PRJNA646272 | ENA
ProteomicsProximity proteomics of C9orf72 dipeptide repeat proteins
Profiling of proximity proteomes of C9orf72-derived dipeptide repeat proteins (poly-GA, poly-GR, poly-PR) in HEK293 cells using BioID assay
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-12-17 | MSV000088581 | MassIVE
UnknownDo nucleic acids moonlight as molecular chaperones?
Not available
S-EPMC4889950 | biostudies-literature
UnknownEngineering and Evolution of Molecular Chaperones and Protein Disaggregases with Enhanced Activity.
Not available
S-EPMC4791398 | biostudies-literature
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