The core objective of this study is to clarify the promoting effect of oral ingestion of microplastics on gastric epithelial cell carcinogenesis, systematically decipher the underlying molecular regulatory mechanisms, focus on investigating the key molecular targets involved in oxidative stress i...

BACKGROUND: Reptiles exhibit a wide variety of skin colors, which serve essential roles in survival and reproduction. However, the molecular basis of these conspicuous colors remains unresolved.

RESULTS: We investigate color morph-enriched Asian vine snakes...

A hallmark of animals is the coordination of whole-body movement. Neurons and muscles are central to this; yet, coordinated movements also exist in sponges that lack these cell types. Sponges are sessile animals with a complex canal system for filter-feeding. They undergo whole-body movements res...

Bacteria can resist antibiotics and toxic substances within demanding ecological settings, such as low oxygen, extreme acid, and during nutrient starvation. MdtEF, a proton motive force-driven efflux pump from the resistance-nodulation-cell division (RND) superfamily, is upregulated in these cond...

The common cutworm (CCW; Spodoptera litura) is one of the major insect pests of soybean in Asia and Oceania. Although quantitative trail loci related to CCW resistance have been introduced into leading soybean cultivars, these do not exhibit sufficient resistance against CCW. Thus, under...

Hepatic steatosis is the initial manifestation of abnormal liver functions and often leads to liver diseases such as non-alcoholic fatty liver disease in humans and fatty liver syndrome in animals. In this study, we conducted a comprehensive analysis of a large chicken population consisting of 70...

Background: Triple-negative breast cancer (TNBC) urgently needs effective therapies due to limited targeted options and unfavorable outcomes. We investigated Trichosanthes kirilowii Maxim formula granules (TKM) using integrated network pharmacology, metabolomics, and molecular pharmacology to cla...

Penicillium italicum (P. italicum) is a primary pathogen responsible for postharvest decay in citrus fruits, resulting in substantial economic losses. Chitosan and titanium dioxide and silver (CTS&TiO2&Ag) composite film solutions activated by combined UV and LED light represent innovativ...

Background: Ulcerative colitis (UC) is a significant and challenging condition in the digestive system, necessitating the development of effective therapeutic interventions. The Daifu decoction (DFD) is derived from the Lizhong decoction, a classic traditional Chinese Medicine (TCM) formula used ...