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MetabolomicsPathogenic NLRP3 mutants form constitutively active inflammasomes resulting in immune-metabolic limitation of IL-1β production

BACKGROUND: Cryopyrin-Associated Periodic Syndrome (CAPS) is an autoinflammatory condition consequence of monoallelic variants in the NLRP3 gene that exacerbate IL-1β production. These variants are gain-of-function, but the exact regulatory mechanism of the NLRP3 CAPS-inflammasom...

2024-01-09 | MTBLS7872 | MetaboLights
UnknownWomen's preferences for and experiences with prenatal genetic testing decision making: Sociodemographic disparities in preference-concordant decision making.
Not available
S-EPMC6421100 | biostudies-literature
UnknownPathogen Surveillance for Acute Infectious Conjunctivitis.
Not available
S-EPMC10623299 | biostudies-literature
UnknownCirculating Tumor Cell Number as a Response Measure of Prolonged Survival for Metastatic Castration-Resistant Prostate Cancer: A Comparison With Prostate-Specific Antigen Across Five Randomized Phase III Clinical Trials.
Not available
S-EPMC5815402 | biostudies-literature
UnknownEffectiveness of simultaneous bilateral visual diaphragm biofeedback under low back pain: influence of age and sex.
Not available
S-EPMC11263192 | biostudies-literature
TranscriptomicsThe Arabidopsis copper transport protein COPT2 and the responses under copper and iron deficiency.
Copper and iron are essential micronutrients for most living organisms because they participate as cofactors in biological processes including respiration, photosynthesis and oxidative stress protection. In many eukaryotic organisms, including yeast and mammals, copper and iron homeostases are highl...
ORGANISM(S): Arabidopsis thaliana 
2013-06-05 | E-GEOD-42642 | biostudies-arrayexpress
UnknownCastleman's disease: Laparoscopic resection of unicentric disease in the hepatic hilum: A case report.
Not available
S-EPMC8219645 | biostudies-literature
TranscriptomicsAnalysis of gene expression in primary fibrotic hepatocytes (from animals treated for a month with CCl4) stimulated with the purinergic agonist, UTP
It is known that extracellular ATP is a Damage Associated Molecular Pattern, however the cellular actions of the nucleotide are not yet undestood. Primary hepatocytes from fibrotic or control C57black mice were stimulated by 24 h with 100 microM of UTP, to understand if P2Y2 receptor activation indu...
ORGANISM(S): Mus musculus 
2019-09-30 | E-MTAB-8302 | biostudies-arrayexpress
UnknownTwo Phase 3 Trials of Gantenerumab in Early Alzheimer's Disease.
Not available
S-EPMC10794000 | biostudies-literature
UnknownPhase I clinical trial of the CYP17 inhibitor abiraterone acetate demonstrating clinical activity in patients with castration-resistant prostate cancer who received prior ketoconazole therapy.
Not available
S-EPMC2849769 | biostudies-literature
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