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ProteomicsMolecular Basis and Cellular Effects of Janus-Class–Driven Cytoplasmic PYK2 Coacervates
Kinase activity is increasingly associated with biomolecular phase separation. Focal adhesion kinase (FAK) forms membrane-associated condensates with paxillin to promote adhesion. Here we show that its paralogue, proline-rich tyrosine kinase 2 (PYK2), undergoes phase separation via a distinct mechan...
ORGANISM(S): Homo sapiens (Human) 
2026-01-11 | PXD072123 | Pride
Focal adhesion Esm2 Cancer Kinase Phase separation Janus class 
UnknownPassenger sequences can promote interlaced dimers in a common variant of the maltose-binding protein.
Not available
S-EPMC6938514 | biostudies-literature
UnknownDesign of a peptide-based vaccine against human respiratory syncytial virus using a reverse vaccinology approach: evaluation of immunogenicity, antigenicity, allergenicity, and toxicity.
Not available
S-EPMC11986473 | biostudies-literature
UnknownThe Prevalence Of β-Thalassemia Mutations in South Western Maharashtra.
Not available
S-EPMC3477466 | biostudies-literature
UnknownThe exceptionally efficient quorum quenching enzyme LrsL suppresses Pseudomonas aeruginosa biofilm production.
Not available
S-EPMC9441902 | biostudies-literature
UnknownCRISPR directed evolution of the spliceosome for resistance to splicing inhibitors.
Not available
S-EPMC6489355 | biostudies-literature
UnknownMolecular Basis for Catalysis and Regulation of the Strigolactone Catabolic Enzyme CXE15.
Not available
S-EPMC12638876 | biostudies-literature
UnknownPYK2 senses calcium through a disordered dimerization and calmodulin-binding element.
Not available
S-EPMC9363500 | biostudies-literature
TranscriptomicsGene expression profiling of lung cancer cells transfected with scrambled siRNA and siRNA targeting the ETS2 gene
ETS2 is a canonical transcriptional factor and member of the ETS family of genes. ETS2 binds to consensus ERE binding sites in a broad spectrum of genes thus affecting many intracellular molecular functions. However, the role of ETS2 in the biology and pathogenesis of lung cancers is still not known...
ORGANISM(S): Homo sapiens 
2013-11-01 | E-GEOD-43459 | biostudies-arrayexpress
ProteomicsExosomes harbor B cell targets in pancreatic adenocarcinoma and exert decoy function against complement-mediated cytotoxicityc
Exosomes harbor B cell targets in pancreatic adenocarcinoma and exert decoy function against complement-mediated cytotoxicityc
ORGANISM(S): Homo sapiens (Human) 
2019-01-21 | PXD011957 | Pride
Exosomes harbor b cell targets in pancreatic adenocarcinoma and exert decoy function against complement-mediated cytotoxicityc 
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