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TranscriptomicsTargeting resistance to Smoothened antagonists by inhibiting the PI3K pathway
Mutations in Hedgehog (Hh) pathway genes, leading to constitutive activation of Smoothened (Smo), occur in sporadic medulloblastoma, the most common brain cancer in children. Antagonists of Smo induce tumor regression in mouse models of medulloblastoma and hold great promise for targeted therapy fo...
ORGANISM(S): Mus musculus 
2010-09-29 | E-GEOD-19657 | biostudies-arrayexpress
UnknownLink between gut-microbiome derived metabolite and shared gene-effects with hepatic steatosis and fibrosis in NAFLD.
Not available
S-EPMC6151296 | biostudies-literature
UnknownSARS-CoV-2 Vaccine Immunogenicity in Patients with Gastrointestinal Cancer Receiving Systemic Anti-Cancer Therapy.
Not available
S-EPMC9847553 | biostudies-literature
UnknownBritish Society of Gastroenterology/Association of Coloproctology of Great Britain and Ireland/Public Health England post-polypectomy and post-colorectal cancer resection surveillance guidelines.
Not available
S-EPMC6984062 | biostudies-literature
UnknownMagnetic Resonance vs Transient Elastography Analysis of Patients With Nonalcoholic Fatty Liver Disease: A Systematic Review and Pooled Analysis of Individual Participants.
Not available
S-EPMC6294709 | biostudies-literature
UnknownRisk-stratified faecal immunochemical testing (FIT) for urgent colonoscopy in Lynch syndrome during the COVID-19 pandemic.
Not available
S-EPMC10478750 | biostudies-literature
Genomicsena-DATASET-BCCA-06-12-2013-17:57:13:627-21 - samples
Complete set of bam files associated with study EGAS00001000622
EGAD00001000702 | EGA
GenomicsPharmacological and genomic profiling identifies NFκB-targeted treatment strategies for mantle cell lymphoma
Mantle cell lymphoma (MCL) is an aggressive malignancy characterized by poor prognosis, underscoring the need for novel therapeutic strategies1. In this study, we employed large-scale pharmacological profiling of 16 pathway inhibitors across more than 100 hematological cell line models to identify n...
EGAS00001000622 | EGA
UnknownBiallelic variants in ARHGAP19 cause a progressive inherited motor-predominant neuropathy.
Not available
S-EPMC12646654 | biostudies-literature
UnknownCo-design of patient information leaflets for germline predisposition to cancer: recommendations for clinical practice from the UK Cancer Genetics Group (UKCGG), Cancer Research UK (CRUK) funded CanGene-CanVar Programme and the Association of Genetic Nurse Counsellors (AGNC).
Not available
S-EPMC11881048 | biostudies-literature
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