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MetabolomicsAMPK activation induces RALDH+ tolerogenic dendritic cells by rewiring glucose and lipid metabolism.
Dendritic cell (DC) activation and function are underpinned by profound changes in cellular metabolism. Several studies indicate that the ability of DCs to promote tolerance is dependent on catabolic metabolism. Yet the contribution of AMP-activated kinase (AMPK), a central energy sensor promoting c...
2024-08-16 | MTBLS10647 | MetaboLights
MetabolomicsCreatine uptake promotes dendritic cell activation and enhances antitumor immunity

Dendritic cells (DCs) are central regulators of antitumor T cell immunity and are highly sensitive to metabolic cues. However, the therapeutic potential of targeting DC metabolism remains underexplored. Here, we report upregulation of the creatine transporter (CrT; Slc6a8) in intratumora...

2026-03-11 | MTBLS12797 | MetaboLights
TranscriptomicsmiRNA expression profiling of human monocyte-derived dendritic cells (moDCs) during maturation
miRNA expression profiling of human monocyte-derived dendritic cells (moDCs) during maturation. Immature, 4h and 16h LPS-activated moDCs were used. In this study were analysed 2 biological samples of RNA extracted from 4h-post LPS stimulation moDCs and 2 bfrom 16h-post LPS stimulation. The RNA ...
ORGANISM(S): Homo sapiens 
2010-05-15 | E-GEOD-13369 | biostudies-arrayexpress
TranscriptomicsHuman monocyte-derived dendritic cells treated with U0126 or SB203580
Identification of MEK-ERK or p38MAPK dependent genes in human monocyte derived dendritic cells. Dendritic cells (DC) promote tolerance or immunity depending on their maturation state. Previous studies have revealed that DC maturation is enhanced or accelerated upon MEK-ERK signaling pathway inhibiti...
ORGANISM(S): Homo sapiens 
2013-05-03 | E-GEOD-39745 | biostudies-arrayexpress
TranscriptomicsmiR-155 KO in human dendritic cells
In response to inflammatory stimulation, dendritic cells (DCs) have a remarkable pattern of differentiation (maturation) that exhibits specific mechanisms to control immunity. Here, we show that in response to Lipopolysaccharides (LPS), several microRNAs (miRNAs) are regulated in human monocyte-deri...
ORGANISM(S): Homo sapiens 
2009-03-04 | E-GEOD-13296 | biostudies-arrayexpress
TranscriptomicsExpression data from human monocyte-derived dendritic cells treated or not with interleukin 17A (IL-17A)
IL-17A is a pro-inflammatory cytokine that promotes host defense against infections and contributes to the pathogenesis of chronic inflammatory diseases. Dendritic cells (DC) are antigen-presenting cells responsible for adaptive immune responses. Here, we report that IL-17A induces intense remodelin...
ORGANISM(S): Homo sapiens 
2015-03-31 | E-GEOD-53163 | biostudies-arrayexpress
TranscriptomicsHuman monocyte-derived dendritic cells: Control vs Tolerogenic
Transcriptional profiling of human dendritic cells (DC) comparing control (DC generated with GM-CSF plus IL-4) with three different treatments of tolerogenic (DC generated with GM-CSF plus IL-4 and IL-10, or IL-4, IL-10, and IL-6, or IL-4, IL-10, and TGF-b1) Three two-condition experiments, control ...
ORGANISM(S): Homo sapiens 
2009-11-12 | E-GEOD-18921 | biostudies-arrayexpress
TranscriptomicsReal-time quantitative PCR analysis of human dendritic cells
Human CD14 positive monocytes were purified from healthy volunteers' blood and were differentiated to immature dendritic cells in vitro by culturing for five days in the presence of interleukin-4 (IL-4 100 ng/ml) and GM-CSF (75 ng/ml). Immature dendritic cells were activated three different ways for...
ORGANISM(S): Homo sapiens 
2011-05-08 | E-GEOD-29131 | biostudies-arrayexpress
TranscriptomicsExpression analysis of dendritic cells, macrophages and monocytes
Expression profiles at different time points during dendritic cell differentiation (induced by specific culture conditions) including monocytes as well as expression profiles between monocytes and completely differentiated cells (macrophages at day7 and dendritic cells at day7, respectively) were co...
ORGANISM(S): Homo sapiens 
2010-06-16 | E-GEOD-19236 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human monocyte-derived dendritic cells after treatment with with CpG-oligo D19
Human monocyte-derived dendritic cell cultures devoid of contaminating plasmacytoid dendritic cells were treated with the D-type CpG-oligonucleotide D19, with the non-CpG-oligonucleotide control D, or were left untreated. Cells of all treatment groups stemmed from the same donor. 6 h after addition,...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-2859 | biostudies-arrayexpress
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