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ProteomicsMonosomes actively translate synaptic mRNAs in neuronal processes
In order to deal with their huge volume and complex morphology, neurons localize mRNAs and ribosomes near synapses to produce proteins locally. A relative paucity of polyribosomes (considered the active sites of translation) detected in electron micrographs of neuronal processes (axons and dendrites...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-01-27 | PXD016552 | Pride
Neuronal processes Monosomes Mrna Protein synthesis 
TranscriptomicsRedefining the translational status of 80S monosomes
Fully assembled ribosomes exist in two populations: polysomes and monosomes. While the former has been studied extensively, to what extent translation occurs on monosomes and its importance for overall translational output remains controversial. Here, we used ribosome profiling to examine the transl...
ORGANISM(S): Saccharomyces cerevisiae 
2016-02-11 | GSE76117 | GEO
GenomicsHead and Embryo 80S monosomes are much more translationally active than 80S in other tissues
Head and Embryo 80S monosomes are much more translationally active than 80S in other tissues
PRJNA1111495 | ENA
TranscriptomicsRedefining the translational status of 80S monosomes
Fully assembled ribosomes exist in two populations: polysomes and monosomes. While the former has been studied extensively, to what extent translation occurs on monosomes and its importance for overall translational output remains controversial. Here, we used ribosome profiling to examine the transl...
ORGANISM(S): Saccharomyces cerevisiae 
2016-02-11 | E-GEOD-76117 | biostudies-arrayexpress
UnknownJNK activation induced by ribotoxic stress is initiated from 80S monosomes but not polysomes.
Not available
S-EPMC6726213 | biostudies-literature
TranscriptomicsHead and Embryo 80S monosomes are much more translationally active than 80S in other tissues
Translational regulation at the stage of initiation impacts the number of ribosomes translating each mRNA molecule. For example, multiple ribosomes can engage on a single mRNA forming a polysome, resulting in highly efficient protein synthesis. However, the translational activity of single 80S ribos...
ORGANISM(S): Drosophila melanogaster 
2025-03-24 | GSE267425 | GEO
TranscriptomicsMouse cardiac tissue, polysomes and monosomes: Vehicle treated control vs. 25mg/kg DMNQ
Translational profiling of mouse cardiac tissue treated with 25mg/kg DMNQ in 10 ml/kg arachis oil over an acute time course (0.5-120 hours) compared to time matched control animals treated with 10ml/kg saline Two colour microarrays with time matched controls vs 25mg/kg DMNQ cardiac tissue. Before mi...
ORGANISM(S): Mus musculus 
2010-08-06 | E-GEOD-17830 | biostudies-arrayexpress
TranscriptomicsMouse cardiac tissue, polysomes and monosomes: Vehicle treated control vs. 15mg/kg doxorubicin
Translational profiling of mouse cardiac tissue treated with 15mg/kg doxorubicin in 10 ml/kg saline over an acute time course (0.5-120 hours) compared to time matched control animals treated with 10ml/kg saline. Two colour microarrays with time matched controls vs 15mg/kg doxorubicin cardiac tissue....
ORGANISM(S): Mus musculus 
2010-08-05 | E-GEOD-17823 | biostudies-arrayexpress
GenomicsSaccharomyces cerevisiae
Redefining the translational status of 80S monosomes
PRJNA306259 | ENA
GenomicsMus musculus
Mouse cardiac tissue, polysomes and monosomes: Vehicle treated control vs. 15mg/kg doxorubicin
PRJNA123299 | ENA
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