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ProteomicsPLASMA PROTEOMIC ANALYSIS OF RARE BMI-DISCORDANT MONOZYGOTIC TWIN PAIRS
The aim of the current study is to establish the effect of excess body wiehgt and liver fat on plasma proteomic profile without interference from genetic variation. Label-free proteomics (HDMSE) was performed on plasma samples of young healthy monozygotic twins who were discordant for BMI. the twins...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000084372 | MassIVE
TranscriptomicsHumanMethylation450 (450k) data for 79 rheumatoid arthritis disease discordant monozygotic twin pairs
This project contains genome-wide DNA methylation data generated using the HumanMethylation450 BeadChip (Illumina), for 79 rheumatoid arthritis (RA) discordant monozygotic twin pairs. By investigating disease discordant monozygotic twins, DNA methylation can be assessed without the confounding influ...
ORGANISM(S): Homo sapiens 
2018-07-24 | E-MTAB-6988 | biostudies-arrayexpress
TranscriptomicsPhenotypically concordant and discordant monozygotic twins display different DNA copy number variation profiles (SNP)
The exploration of copy number variation (CNV), notably of somatic cells, is an understudied aspect of genome biology. Any differences in the genetic make-up between twins derived from the same zygote represent an extreme example of somatic variation. We studied 19 pairs of monozygotic twins with ei...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-9608 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human monozygotic twins discordant for bipolar disorder
To identify genes dysregulated in bipolar disorder (BD1) we carried out global gene expression profiling using whole-genome microarrays. To minimize genetic variation in gene expression levels between cases and controls we compared expression profiles in lymphoblastoid cell lines from monozygotic tw...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7036 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of leukemic cells of monozygotic twins
We established gene expression profiles of diagnostic bone marrow samples of monozygotic twins with acute lymphoblastic leukemia. We established technical duplicates for each twin.
ORGANISM(S): Homo sapiens 
2004-10-01 | E-MEXP-122 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of fat biopsies from monozygotic twins discordant for body mass index to elucidate the effects of acquired obesity
Elucidating the effects of acquired obesity by comparison of fat biopsies from monozygotic twins discordant for BMI.
ORGANISM(S): Homo sapiens 
2008-02-15 | E-MEXP-1425 | biostudies-arrayexpress
TranscriptomicsGene Expression in Peripheral Blood Leucocytes in Monozygotic Twins Discordant for Chronic Fatigue
Background. Chronic fatiguing illness remains a poorly understood syndrome of unknown pathogenesis. We attempted to identify biomarkers for chronic fatiguing illness using microarrays to query the transcriptome in peripheral blood leukocytes. Methods. Cases were 44 individuals who were clinically ev...
ORGANISM(S): Homo sapiens 
2009-05-12 | E-GEOD-16059 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human healthy monozygotic twins vs unrelated individuals to understand the genetic basis of variation in gene expression between normal human individuals
Natural variation in gene expression among healthy human individuals has been largely unexplored. In order to understand the genetic basis of variation in gene expression between normal human individuals, we need to obtain genome-wide expression data from various populations. Studies in monozygotic ...
ORGANISM(S): Homo sapiens 
2008-08-20 | E-GEOD-928 | biostudies-arrayexpress
TranscriptomicsPeripheral Blood Cells Gene Expression Profiles from Discordant Monozygotic Twins with Systemic Autoimmune disease (SAIDs)
Gene expression profiling in peripheral blood cells from monozygotic twin pairs with various sytemic autoimmune diseases revealed 92 genes that could discriminate between MZ twin pairs and unrelated-matched controls. No genes were found that could discriminate between proband and unaffected twin pai...
ORGANISM(S): Homo sapiens 
2010-12-30 | E-GEOD-24060 | biostudies-arrayexpress
GenomicsGenome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis

Monozygotic (MZ) twins have been widely employed for dissection of the relative contributions of genetics and environment in disease. In multiple sclerosis (MS), an autoimmune demyelinating disease that commonly causes neurodegeneration and disability in young adults, disease discordance in M...

phs000239.v2.p1 | EGA
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