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GenomicsBromodomain-dependent stage-specific male genome programming by Brdt [ChIP-Seq]
Male germ cell differentiation is a highly regulated multistep process initiated by the commitment of progenitor cells into meiosis and characterized by major chromatin reorganizations in haploid spermatids. We report here that a single member of the double bromodomain BET factors, Brdt, is a master...
ORGANISM(S): Mus musculus 
2012-08-30 | E-GEOD-39908 | biostudies-arrayexpress
TranscriptomicsChromatin-to-nucleoprotamine transition is controlled by the histone H2B variant TH2B [Illumina]
The conversion of male germ cell chromatin to a nucleoprotamine structure is fundamental to the life cycle yet the underlying molecular details remain obscure. Here we show that an essential step is the genome-wide incorporation of TH2B, a histone H2B variant of hitherto unknown function. Using mous...
ORGANISM(S): Mus musculus 
2013-10-17 | E-GEOD-46136 | biostudies-arrayexpress
TranscriptomicsAcetylation at the lateral surface of the nucleosome at lysine 64 of H3 regulates chromatin dynamics and defines transcriptionally active chromatin
Post-translational modifications of proteins have emerged as a major mechanism for regulating gene expression. Yet our understanding of how histone modifications directly affect chromatin function remains limited. Here, we investigate acetylation of histone H3 at lysine 64 (H3K64ac), a previously un...
ORGANISM(S): Mus musculus 
2014-03-18 | E-GEOD-35355 | biostudies-arrayexpress
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