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ProteomicsCRISPR targeting of FOXL2 c.402C>G mutation reduces malignant phenotype in granulosa tumor cells and identifies anti-tumoral compounds
FOXL2 is a transcription factor that plays a key role in sex determination, ovary development and maintenance. Mutations related to this gene have been described in syndromes involving premature ovarian failure and granulosa cell tumors. This kind of rare cancer (less than 5% of diagnosed ovarian ca...
ORGANISM(S): Homo sapiens (Human) 
2025-03-15 | PXD053682 | Pride
Tmt Rare cancer Crispr Granulosa cell tumor Proteomics Foxl2 
MetabolomicsMetabolomics Analysis Identifies Glutamic acid and Cystine imbalances in COVID-19 Patients Without Comorbid Conditions. Implications on Redox Homeostasis and COVID-19 Pathophysiology

It is well known that the presence of comorbidities and age-related health issues may hide biochemical and metabolic features triggered by SARS-CoV-2 infection and other diseases associated to hypoxia, as they are by themselves chronic inflammatory conditions that may potentially disturb metaboli...

2024-08-26 | MTBLS5011 | MetaboLights
UnknownCIBERER: Spanish national network for research on rare diseases: A highly productive collaborative initiative.
Not available
S-EPMC9305285 | biostudies-literature
ProteomicsBenefits of FAIMS to improve the proteome coverage of deteri-orated, and/or cross-linked TMT 10-plex FFPE tissue and plas-ma-derived exosomes samples
The analysis of complex protein mixtures, such as FFPE tissue or plasma exosomes samples, is a challenge nowadays due to the low proteome coverage achieved by mass spectrometers nowadays. We have here investigated the benefits of FAIMS technology coupled to the Orbitrap Exploris 480 mass spectromete...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD045362 | Pride
Orbitrap exploris 480 Mass spectrometry Proteomics Faims Ffpe tissue Exosomes 
ProteomicsBenefits of FAIMS to improve the proteome coverage of deteriorated, and/or cross-linked TMT 10-plex FFPE tissue and plas-ma-derived exosomes samples
The analysis of complex protein mixtures, such as FFPE tissue or plasma exosomes samples, is a challenge nowadays due to the low proteome coverage achieved by mass spectrometers nowadays. We have here investigated the benefits of FAIMS technology coupled to the Orbitrap Exploris 480 mass spectromete...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD045367 | Pride
Orbitrap exploris 480 Mass spectrometry Proteomics Faims Ffpe tissue Exosomes 
ProteomicsBenefits of FAIMS to improve the proteome coverage of hard-to-analyze TMT 10-plex FFPE tissue and plasma-derived exosomes samples
The analysis of complex protein mixtures, such as FFPE tissue or plasma exosomes samples, is a challenge nowadays due to the low proteome coverage achieved by mass spectrometers nowadays. We have here investigated the benefits of FAIMS technology coupled to the Orbitrap Exploris 480 mass spectromete...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD042596 | Pride
Orbitrap exploris 480 Mass spectrometry Proteomics Faims Ffpe tissue Exosomes 
ProteomicsBenefits of FAIMS to improve the proteome coverage of hard-to-analyze TMT 10-plex FFPE tissue and plasma-derived exosomes samples
The analysis of complex protein mixtures, such as FFPE tissue or plasma exosomes samples, is a challenge nowadays due to the low proteome coverage achieved by mass spectrometers nowadays. We have here investigated the benefits of FAIMS technology coupled to the Orbitrap Exploris 480 mass spectromete...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD042601 | Pride
Orbitrap exploris 480 Mass spectrometry Proteomics Faims Ffpe tissue Exosomes 
ProteomicsBenefits of FAIMS to improve the proteome coverage of hard-to-analyze TMT 10-plex FFPE tissue and plasma-derived exosomes samples
The analysis of complex protein mixtures, such as FFPE tissue or plasma exosomes samples, is a challenge nowadays due to the low proteome coverage achieved by mass spectrometers nowadays. We have here investigated the benefits of FAIMS technology coupled to the Orbitrap Exploris 480 mass spectromete...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD042597 | Pride
Orbitrap exploris 480 Mass spectrometry Proteomics Faims Ffpe tissue Exosomes 
ProteomicsFunctional proteomics characterization of the role of SPRYD7 in colorectal cancer progression and metastasis
SPRY domain-containing protein 7 (SPRYD7) is a barely known protein identified by spatial proteomics as upregulated in highly-metastatic to liver KM12SM colorectal cancer (CRC) cells in comparison to its isogenic poorly-metastatic KM12C CRC cells. Here, we aimed at analyzing SPRYD7 role in CRC by fu...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD042874 | Pride
Colorectal cancer  spryd7  cancer metastasis  proteomics  protein dysregulation  interactome 
ProteomicsFunctional proteomics characterization of the role of SPRYD7 in colorectal cancer progression and metastasis
SPRY domain-containing protein 7 (SPRYD7) is a barely known protein identified by spatial proteomics as upregulated in highly-metastatic to liver KM12SM colorectal cancer (CRC) cells in comparison to its isogenic poorly-metastatic KM12C CRC cells. Here, we aimed at analyzing SPRYD7 role in CRC by fu...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD042901 | Pride
Colorectal cancer  spryd7  cancer metastasis  proteomics  protein dysregulation  interactome 
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