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TranscriptomicsImpaired TLR3-mediated immune responses from macrophages of patients chronically infected with Hepatitis C virus
Hepatitis C virus (HCV) is the most common chronic blood-borne infection in the United States with the majority of patients becoming chronically infected and a subset (20%) progressing to cirrhosis and hepatocellular carcinoma. Individual variations in immune responses may help define successful res...
ORGANISM(S): Homo sapiens 
2013-03-05 | E-GEOD-40812 | biostudies-arrayexpress
UnknownTargeted androgen pathway suppression in localized prostate cancer: a pilot study.
Not available
S-EPMC3887479 | biostudies-literature
UnknownCognition, functional capacity, and self-reported disability in women with posttraumatic stress disorder: examining the convergence of performance-based measures and self-reports.
Not available
S-EPMC4127348 | biostudies-literature
UnknownTargeting Androgen Receptor and DNA Repair in Metastatic Castration-Resistant Prostate Cancer: Results From NCI 9012.
Not available
S-EPMC6075827 | biostudies-literature
UnknownEffect of Zuranolone vs Placebo in Postpartum Depression: A Randomized Clinical Trial.
Not available
S-EPMC8246337 | biostudies-literature
UnknownIntense androgen-deprivation therapy with abiraterone acetate plus leuprolide acetate in patients with localized high-risk prostate cancer: results of a randomized phase II neoadjuvant study.
Not available
S-EPMC4226804 | biostudies-literature
TranscriptomicsSRRM4 Expression and the Loss of REST Activity May Promote the Emergence of the Neuroendocrine Phenotype in Castration-Resistant Prostate Cancer
The neuroendocrine (NE) phenotype is associated with the development of metastatic castration-resistant prostate cancer (CRPC). Our objective was to characterize the molecular features of the NE phenotype in CRPC. Expression of chromogranin A (CHGA), synaptophysin (SYP), androgen receptor (AR), and ...
ORGANISM(S): Homo sapiens 
2015-06-24 | E-GEOD-66187 | biostudies-arrayexpress
TranscriptomicsA Characterization of Osteoblastic and Osteolytic Proteins in Prostate Cancer Bone Metastases
Our goal was to determine whether previously identified and novel proteins are associated with the osteoblastic or osteolytic response in clinical specimens of PCa bone metastases. Custom Agilent 44K whole human genome expression oligonucleotide microarrays were used to profile 14 PCa metastases fro...
ORGANISM(S): Homo sapiens 
2013-05-03 | E-GEOD-41619 | biostudies-arrayexpress
TranscriptomicsMolecular Profiling of Metastatic Prostate Carcinoma Reveals Substantial Inter-individual and Limited Intra-individual Diversity: Implications for Precision Oncology
Prostate cancers exhibit a spectrum of molecular aberrations of which a substantial subset are amenable to targeted therapeutics. To determine the diversity of somatic alterations present in metastasis within and between individuals we characterized the genomic landscapes of 176 tumors acquired from...
ORGANISM(S): Homo sapiens 
2015-12-18 | E-GEOD-74685 | biostudies-arrayexpress
MetabolomicsDietary restriction of cysteine and methionine sensitizes gliomas to ferroptosis and induces alterations in energetic metabolism

Ferroptosis is mediated by lipid peroxidation of phospholipids containing polyunsaturated fatty acyl moieties. Glutathione, the key cellular antioxidant capable of inhibiting lipid peroxidation via the activity of the enzyme glutathione peroxidase 4 (GPX-4), is generated directly from the sulfur-...

2023-01-11 | MTBLS5959 | MetaboLights
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