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ProteomicsDrug Affinity Responsive Target Stability unveils Filamins as biological targets for Artemetin, an anti-cancer flavonoid.
Artemetin is a valuable 5-hydroxy-3,6,7,3',4'-pentamethoxyflavone found in many different medicinal plants with a very good oral bioavailability and drug-likeness values endowed with numerous bioactivities such as anti-inflammatory and anti-cancer ones. Here, a multi-disciplinary strategy has been d...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD034776 | Pride
Anti-cancer. Bioactive natural compounds Drug affinity responsive target stability Cytoskeleton Proteomics 
TranscriptomicsChanges in gene expression analysis of alphaCD3alpha/CD28 activated human naive and memory regulatory T cells (Treg) upon IL-7 treatment as measured by quantitative PCR array
This study evaluated changes in gene expression upon IL-7 treatment in human naive and memory Treg. CD4+CD25+CD127low naïve and memory Treg were isolated from fresh PBMC and separately stimulated with ?CD3?/CD28 coupled beads (Invitrogen-Dynal) at a 1:10 bead/T cell ratio, treated with or without 10...
ORGANISM(S): Homo sapiens 
2012-09-12 | E-GEOD-40755 | biostudies-arrayexpress
UnknownMutant p53K120R expression enables a partial capacity to modulate metabolism.
Not available
S-EPMC9549157 | biostudies-literature
UnknownEtoposide-resistance in a neuroblastoma model cell line is associated with 13q14.3 mono-allelic deletion and miRNA-15a/16-1 down-regulation.
Not available
S-EPMC6137223 | biostudies-literature
UnknownProton versus Photon Radiotherapy for Pediatric Central Nervous System Malignancies: A Systematic Review and Meta-Analysis of Dosimetric Comparison Studies.
Not available
S-EPMC6900940 | biostudies-literature
UnknownOne-year cognitive follow-up of COVID-19 hospitalized patients.
Not available
S-EPMC9111730 | biostudies-literature
UnknownCarbamoyl-Phosphate Synthase 1 as a Novel Target of Phomoxanthone A, a Bioactive Fungal Metabolite.
Not available
S-EPMC7356042 | biostudies-literature
UnknownThe spectrum of subclonal TP53 mutations in chronic lymphocytic leukemia: A next generation sequencing retrospective study.
Not available
S-EPMC10086786 | biostudies-literature
UnknownTime to first treatment and P53 dysfunction in chronic lymphocytic leukaemia: results of the O-CLL1 study in early stage patients.
Not available
S-EPMC7595214 | biostudies-literature
UnknownAn integrated transcriptomic and proteomic approach to identify the main Torymus sinensis venom components.
Not available
S-EPMC7930282 | biostudies-literature
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