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ProteomicsDIA to inform Triple Quad Assay development
Mass spectrometry based targeted proteomics methods provide sensitive and high-throughput analysis of selected proteins. To develop a targeted bottom-up proteomics assay, peptides must be evaluated as proxies for the measurement of a protein or proteoform in a biological matrix. Candidate peptide se...
ORGANISM(S): Homo Sapiens 
2025-06-11 | PXD059611 | panorama
UnknownAntioxidants for Alzheimer disease: a randomized clinical trial with cerebrospinal fluid biomarker measures.
Not available
S-EPMC3661272 | biostudies-literature
ProteomicsDevelopment of highly multiplex targeted proteomics assays in biofluids using a nominal mass ion trap mass spectrometer
The development of targeted assays that monitor biomedically relevant proteins is an important step in bridging discovery experiments to large scale clinical studies. Targeted assays are currently unable to scale to hundreds or thousands of targets. We demonstrate the generation of large-scale assay...
ORGANISM(S): Homo Sapiens Gallus Gallus 
2026-01-12 | PXD065471 | panorama
ProteomicsAlzheimer's Disease Isomerization
Amino acid isomerization is a spontaneous chemical modification potentially related to the underlying causes of Alzheimer’s disease (AD). We demonstrate that data-independent acquisition mass spectrometry can be used to characterize isomerization in complex protein mixtures. Examination of a large c...
ORGANISM(S): Homo Sapiens 
2022-03-16 | PXD025668 | panorama
ProteomicsA Peptide-Centric Quantitative Proteomics Dataset for the Phenotypic Assessment of Alzheimer’s Disease
Alzheimer’s disease (AD) is a looming public health disaster with limited interventions. Desperately needed progress in therapeutic development rests on more detailed understanding of molecular pathogenesis. The vast majority of existing data for AD pathogenesis in humans is from standard neuropatho...
ORGANISM(S): Homo Sapiens 
2023-04-18 | PXD034525 | panorama
ProteomicsMag-Net: Rapid enrichment of membrane-bound particles enables high coverage quantitative analysis of the plasma proteome
Membrane-bound particles in plasma are composed of exosomes, microvesicles, and apoptotic bodies and represent ~1-2% of the total protein composition. Proteomic interrogation of this subset of plasma proteins augments the representation of tissue-specific proteins, representing a “liquid biopsy,” wh...
ORGANISM(S): Homo Sapiens 
2025-07-02 | PXD042947 | panorama
UnknownDiagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium.
Not available
S-EPMC5496518 | biostudies-literature
UnknownTest-retest resting-state fMRI in healthy elderly persons with a family history of Alzheimer's disease.
Not available
S-EPMC4603392 | biostudies-literature
UnknownAssessment of white matter hyperintensity severity using multimodal magnetic resonance imaging.
Not available
S-EPMC10636521 | biostudies-literature
UnknownAmyloid and Tau Pathology Associations With Personality Traits, Neuropsychiatric Symptoms, and Cognitive Lifestyle in the Preclinical Phases of Sporadic and Autosomal Dominant Alzheimer's Disease.
Not available
S-EPMC7415608 | biostudies-literature
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