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TranscriptomicsEffects of KAT2B and WDR5 depletion on hepatocyte gene expression
During fasting, increases in circulating pancreatic glucagon maintain glucose balance by up-regulating hepatic gluconeogenesis. Triggering of the cAMP pathway stimulates the gluconeogenic program through the phosphorylation of CREB and via the de-phosphorylation of the CREB coactivator CRTC2. Hormon...
ORGANISM(S): Mus musculus 
2014-04-21 | E-GEOD-47179 | biostudies-arrayexpress
TranscriptomicsFeedback Inhibition of CREB Signaling Promotes Beta Cell Dysfunction in Insulin Resistance.
Although persistent elevations in circulating glucose concentrations promote compensatory increases in pancreatic islet mass, unremitting insulin resistance causes a deterioration in beta cell function that disrupts glucose balance and signals the progression to diabetes 1. Glucagon like Peptide 1 (...
ORGANISM(S): Rattus norvegicus 
2015-02-23 | E-GEOD-60158 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human HEK293T to characterize CREB target genes in different tissue types
The CREB family of transcription factors stimulates cellular gene expression following phosphorylation at a conserved serine (Ser133 in CREB1) in response to cAMP and other extracellular signals. In order to characterize CREB target genes in various tissues, we give a cAMP agonist, forskolin (FSK), ...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-2060 | biostudies-arrayexpress
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