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TranscriptomicsNascent elongating transcript sequencing (NET-seq) for Escherichia coli and Bacillus subtilis reveals a consensus pause sequence enriched at translation start sites.
Transcription by RNA polymerase (RNAP) is interrupted by pauses that play diverse regulatory roles. Although individual pauses have been studied in vitro, the determinants of pauses in vivo and their distribution throughout the bacterial genome remain unknown. Using nascent transcript sequencing we ...
ORGANISM(S): Bacillus subtilis 
2014-05-05 | E-GEOD-56720 | biostudies-arrayexpress
TranscriptomicsRho directs widespread termination of intragenic and stable RNA transcription
The transcription termination factor Rho is a global regulator of RNA polymerase (RNAP). Although individual Rho-dependent terminators have been studied extensively, less is known about the sites of RNAP regulation by Rho on a genome-wide scale. Using chromatin immunoprecipitation and microarrays (...
ORGANISM(S): Escherichia coli 
2010-05-18 | E-GEOD-16562 | biostudies-arrayexpress
TranscriptomicsRegulator trafficking on bacterial transcription units in vivo
The in vivo trafficking patterns on DNA by the bacterial regulators of transcript elongation Sigma70, Rho, NusA, and NusG and the explanation for high promoter-proximal levels or peaks of RNA polymerase (RNAP) are unknown. Genome-wide ChIP-chip on E. coli revealed distinct association patterns of r...
ORGANISM(S): Escherichia coli 
2010-05-14 | E-GEOD-13938 | biostudies-arrayexpress
TranscriptomicsDksA Guards Elongating RNA Polymerase Against Ribosome-Stalling-Induced Arrest
In bacteria, translation-transcription coupling inhibits RNA polymerase (RNAP) stalling. We present evidence suggesting that, upon amino acid starvation, inactive ribosomes promote rather than inhibit RNAP stalling. We developed an algorithm to evaluate genome-wide polymerase progression independent...
ORGANISM(S): Escherichia coli 
2014-04-21 | E-GEOD-54669 | biostudies-arrayexpress
UnknownIntracellular proteomics and extracellular vesiculomics as a metric of disease recapitulation in 3D-bioprinted aortic valve arrays.
Not available
S-EPMC10901368 | biostudies-literature
UnknownA CD25-biased interleukin-2 for autoimmune therapy engineered via a semi-synthetic organism.
Not available
S-EPMC10966033 | biostudies-literature
UnknownCough-Specific Quality of Life Predicts Disease Progression Among Patients With Interstitial Lung Disease: Data From the Pulmonary Fibrosis Foundation Patient Registry.
Not available
S-EPMC9808640 | biostudies-literature
UnknownPrecore and Basal Core Promoter Hepatitis B Virus (HBV) Variants Are Present From a Young Age and Differ Across HBV Genotypes.
Not available
S-EPMC8570313 | biostudies-literature
TranscriptomicsImmunological Genome Project data Phase 1
Gene-expression microarray datasets generated as part of the Immunological Genome Project (ImmGen). Primary cells from multiple immune lineages are isolated ex-vivo, primarily from young adult B6 male mice, and double-sorted to >99% purity. RNA is extracted from cells in a centralized manner, amplif...
ORGANISM(S): Mus musculus 
2009-05-02 | E-GEOD-15907 | biostudies-arrayexpress
UnknownPatient-reported outcomes in a large North American cohort living with chronic hepatitis B virus: a cross-sectional analysis.
Not available
S-EPMC6989387 | biostudies-literature
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