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TranscriptomicsTrans-effects of chromosome aneuploidies on DNA methylation patterns: DNA methylation analysis of Down syndrome in human brain tissues and cells
Background: Trisomy 21 causes Down syndrome (DS), but the mechanisms by which the extra chromosome leads to deficient intellectual and immune function are not well understood. Results: Here, we profile CpG methylation in DS and control cerebral and cerebellar cortex of adults and cerebrum of fetuse...
ORGANISM(S): Homo sapiens 
2015-10-30 | E-GEOD-74486 | biostudies-arrayexpress
TranscriptomicsGenotyping of human family trios using placental cDNA, placental genomic DNA (gDNA) and gDNA from both parents to find new imprinted genes
Twenty-three family trios of placental cDNA, placental genomic DNA (gDNA) and gDNA from both parents were tested using Illumina SNP arrays to find new imprinted genes to ascertain the extent of allele specific expression in this tissue.
ORGANISM(S): Homo sapiens 
2010-04-15 | E-TABM-796 | biostudies-arrayexpress
GenomicsTrans-effects of sub-chromosomal duplications on DNA methylation patterns in mouse models of Down syndrome: whole genome bisulfite sequencing of cerebral samples from Dp(10)1Yey and Dp(16)1Yey mouse models.
Background: Trisomy 21 causes Down syndrome (DS), but the mechanisms by which the extra chromosome leads to deficient intellectual and immune function are not well understood. Results: Here, we profile CpG methylation in DS and control cerebral and cerebellar cortex of adults and cerebrum of fetuse...
ORGANISM(S): Mus musculus 
2015-10-30 | E-GEOD-74505 | biostudies-arrayexpress
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