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ProteomicsMulti-omics profiling of hypertrophic cardiomyopathy reveals altered mechanisms in mitochondrial dynamics and excitation-contraction coupling
Hypertrophic cardiomyopathy is one of the most common inherited cardiomyopathies, and a leading cause of sudden cardiac death in young adults. Despite profound insights into the genetics, there is imperfect correlation between mutation and clinical prognosis, suggesting complex molecular cascades dr...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD039613 | Pride
Myectomy Hipsc-cm Hcm 
ProteomicsGlobal Phospho-Proteomic Profiling of Pathway-Level Molecular Alterations in Barrett’s Esophagus
In the present study, we applied deep, quantitative mass-spectrometry to clinical samples (Barrett’s esophagus and matched adjacent normal biopsies) to gain a mechanistic understanding of the molecular pathways associated with disease progression. From our rich LC/MS profiles, we identified a robust...
ORGANISM(S): Homo sapiens (Human) 
2022-08-11 | PXD023293 | Pride
Biopsy  systems biology  mass spectrometry  disease signature 
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