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TranscriptomicsTranscriptome profiling of peripheral blood from patients with hypertrophic cardiomyopathy (HCM) compared to healthy controls
This study investigates the molecular mechanisms of hypertrophic cardiomyopathy (HCM), a common genetic heart disease where the link between cardiac remodeling and immune response is not fully understood. We aimed to identify novel diagnostic biomarkers and explore transcriptomic alterations in peri...
ORGANISM(S): Homo sapiens 
2025-11-17 | E-MTAB-15843 | biostudies-arrayexpress
TranscriptomicsmiRNA expression profiles in the serum of cats with hypertrophic cardiomyopathy compared to healthy cats
MicroRNAs negatively regulate gene expression and may serve as biomarkers for human cardiomyopathy. In the domestic cat, hypertrophic cardiomyopathy (HCM) represents the most common primary cardiomyopathy. In humans, the etiology of HCM is linked to mutations in genes of contractile muscle proteins,...
ORGANISM(S): Felis catus 
2015-07-22 | E-GEOD-49427 | biostudies-arrayexpress
ProteomicsProteomic profiling of a large cohort of HCM patients: genotype-specific protein changes
Hypertrophic cardiomyopathy (HCM) is characterized by asymmetric left ventricular (LV) hypertrophy and diastolic dysfunction, which leads to LV outflow tract obstruction (LVOTO) in the majority of cases. Mutations in genes encoding sarcomeric proteins cause HCM and are identified in more than half o...
ORGANISM(S): Homo sapiens (Human) 
2021-01-14 | PXD012467 | Pride
Myectomy Hypertrophic cardiomyopathy Label-free Hcm Spectral counting 
ProteomicsProteomics analyses reveal potential therapeutic strategies for HCM
Proteomics was performed to facilitate the understanding of the metabolic alterations in HCM patients from proteinlevel
ORGANISM(S): Homo sapiens (Human) 
2022-03-22 | PXD032097 | Pride
Human Hcm Heart tissue Therapeutic strategies 
Transcriptomics5'RNA-seq analysis of hypertrophic cardiomyopathy (HCM) in mice that carry a human missence mutation in the myosin heavy chain
We developed a 5'RNA-seq methodology to concurrently assess gene expression and start-site usage changes. We applied this methodology to study hypertrophic cardiomyopathy in mice harboring a human deleterious mutation. 5'RNA-seq analysis of transcriptomes from mouse hearts with or without hypertroph...
ORGANISM(S): Mus musculus 
2013-11-05 | E-GEOD-52038 | biostudies-arrayexpress
TranscriptomicsThe impact of a phytoestrogen-rich diet on cardiac gene expression in the context of HCM
A soy diet worsens the progression of an inherited form of hypertrophic cardiomyopathy (HCM) in male mice when compared to casein-fed mice. Females are largely resistant to this diet effect and better preserve cardiac function. We hypothesized that the abundant phytoestrogens found in soy are mainly...
ORGANISM(S): Mus musculus 
2011-06-02 | E-GEOD-29648 | biostudies-arrayexpress
ProteomicsA new multiplexed plasma biomarker panel developed using targeted proteomics and machine learning has diagnostic and prognostic potential in children with hypertrophic cardiomyopathy
Background Hypertrophic cardiomyopathy (HCM) is defined clinically by pathological left ventricular hypertrophy (LVH). We have previously developed a plasma proteomics biomarker panel that correlates with clinical markers of disease severity and sudden cardiac death (SCD) risk in adult patients with...
ORGANISM(S): Homo sapiens (Human) 
2024-07-03 | PXD045304 | Pride
Childhood-onset hcm proteomics 
ProteomicsA Proteomic Analysis of the Myocardium in Hypertrophic Obstructive Cardiomyopathy
Hypertrophic cardiomyopathy (HCM) is characterised by a complex phenotype that is only partly explained by the biological effects of individual genetic variants. The aim of this study was to use proteomic analysis of myocardial tissue to explore thepostgenomic phenotype.
ORGANISM(S): Homo sapiens (Human) 
2019-08-14 | PXD011994 | Pride
Hypertrophic cardiomyopathy fibrosis proteomics 
GenomicsScRNA-seq shows cardiac fibrosis and immune microenvironment activation in HCM mice
ScRNA-seq shows cardiac fibrosis and immune microenvironment activation in HCM mice
PRJNA1273908 | ENA
ProteomicsInhibition of miR-199a-3p in a murine hypertrophic cardiomyopathy (HCM) model attenuates fibrotic remodeling
Background: Hypertrophic cardiomyopathy (HCM) is an autosomal dominant genetic disorder, characterized by cardiomyocyte hypertrophy, cardiomyocyte disarray and fibrosis, which has a prevalence of ~1:200-500 and predisposes individuals to sudden death and heart failure. The mechanisms through which d...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-26 | PXD042904 | Pride
Proteomics Micro rna Cardiac fibroblast Secretome 
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