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MetabolomicsOxidative phosphorylation is a metabolic vulnerability of endocrine therapy and palbociclib resistant metastatic breast cancers
Resistance to endocrine treatments and CDK4/6 inhibitors is considered a near-inevitability in most patients with estrogen receptor positive breast cancers (ER + BC). By genomic and metabolomics analyses of patients' tumours, metastasis-derived patient-derived xenografts (PDX) and isogenic cell line...
2023-06-27 | MTBLS3342 | MetaboLights
TranscriptomicsGDNF-RET signaling as a target in aromatase inhibitor resistant breast cancers
Understanding the complex molecular mechanisms underlying resistance to endocrine therapy is a major challenge in the treatment of estrogen receptor-positive (ER+) breast cancers. We have previously demonstrated that glial cell line-derived neurotrophic factor (GDNF) signaling via the receptor tyros...
ORGANISM(S): Homo sapiens 
2013-01-17 | E-MEXP-3662 | biostudies-arrayexpress
TranscriptomicsMesenchymal to amoeboid transition is associated with stem-like features of melanoma cells
Cellular plasticity confers cancer cells the ability to adapt to micro-environmental changes, a fundamental requirement for tumour progression and metastasis. The epithelial to mesenchymal transition (EMT) is a transcriptional programme associated with increased cell motility and stemness. Beside EM...
ORGANISM(S): Homo sapiens 
2014-04-22 | E-GEOD-52246 | biostudies-arrayexpress
UnknownDalfampridine to Improve Balance in Multiple Sclerosis: Substudy from a Randomized Placebo-Controlled Trial.
Not available
S-EPMC7283428 | biostudies-literature
ProteomicsIDENTIFICATION OF BIOCHEMICAL AND MOLECULAR MARKERS OF EARLY AGING AND CELLULAR STRESS IN CHILDHOOD CANCER SURVIVORS (CCS) PATIENTS
Survival rates of Childhood Cancer Survivors (CCS) have improved tremendously over the past four decades. Unfortunately, treatments are associated with increased risk for developing early onset of chronic diseases, typical of aging, and secondary cancer. Although several studies have described a phe...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD021960 | Pride
Aerobic metabolism  early aging  mitochondria biogenesis  metabolism modulation 
TranscriptomicsTranscription profiling of cultured rat cardiomyocytes grown with eicosapentaenoic acid or docosahexaenoic acid supplementation in the culture media
Despite the recognized protective effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in cardiovascular diseases, and the demonstration of the control of gene expression by polyunsaturated fatty acids (PUFAs), the effects of these n-3 fatty acids on the whole genoma has never been ...
ORGANISM(S): Rattus norvegicus 
2008-05-07 | E-GEOD-4327 | biostudies-arrayexpress
UnknownLarge scale genotype-phenotype analyses indicate that novel prognostic tools are required for families with facioscapulohumeral muscular dystrophy.
Not available
S-EPMC3808686 | biostudies-literature
UnknownNeutral Lipid Storage Diseases: clinical/genetic features and natural history in a large cohort of Italian patients.
Not available
S-EPMC5427600 | biostudies-literature
UnknownMolecular testing on bronchial washings for the diagnosis and predictive assessment of lung cancer.
Not available
S-EPMC7463327 | biostudies-literature
UnknownA novel clinical tool to classify facioscapulohumeral muscular dystrophy phenotypes.
Not available
S-EPMC4893383 | biostudies-literature
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