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TranscriptomicsGenome-wide haplotyping of human single cells
A method to infer genome-wide haplotypes from the analysis of one or two single (human) cells has tremendous applicative value. It would revolutionize not only preimplantation genetic diagnosis of in vitro fertilized human embryos in the clinic, but also animal breeding programs by enabling genome-w...
ORGANISM(S): Homo sapiens 
2012-10-01 | E-GEOD-17318 | biostudies-arrayexpress
TranscriptomicsSingle-cell copy number varation detection
Detection of genomic rearrangements from a single cell instead of a population of cells is an emerging research technique with important applications in the study of human fertility, constitutional chromosomal disorders, and tumor progression. Here, we develop a method to improve the detection of si...
ORGANISM(S): Homo sapiens 
2011-08-23 | E-GEOD-27892 | biostudies-arrayexpress
TranscriptomicsAn experimental loop design improves the detection of congenital chromosomal aberrations by array CGH
Comparative genomic hybridization microarrays (array CGH or molecular karyotyping) for the detection of congenital chromosomal aberrations is the application of microarray technology that is coming fastest into routine clinical application. When using a two-channel microarray of genomic DNA probes f...
ORGANISM(S): Homo sapiens 
2010-05-25 | E-GEOD-6538 | biostudies-arrayexpress
TranscriptomicsSingle-cell aneuploidy detection by array CGH
In this study, we extend array CGH technology by making the accurate detection of chromosomal imbalances possible from a single fibroblast and blastomere following Phi29 DNA polymerase amplification. Firstly, array CGH experiments were performed on four different fibroblast cell lines, derived from ...
ORGANISM(S): Homo sapiens 
2010-07-01 | E-GEOD-3642 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis mutants (elo2, elo3, drl1-2 and ang4) vs the wild type Ler strain
Microarray transcript profiling and RNA interference are two new technologies crucial for large-scale gene function studies in multicellular eukaryotes. Both rely on sequence-specific hybridization between complementary nucleic acid strands, inciting us to create a collection of gene-specific sequen...
ORGANISM(S): Arabidopsis thaliana 
2004-05-07 | E-MEXP-30 | biostudies-arrayexpress
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