An experimental loop design improves the detection of congenital chromosomal aberrations by array CGH

ABSTRACT: Comparative genomic hybridization microarrays (array CGH or molecular karyotyping) for the detection of congenital chromosomal aberrations is the application of microarray technology that is coming fastest into routine clinical application. When using a two-channel microarray of genomic DNA probes for array CGH, the basic setup consists in hybridizing a patient sample against a normal reference sample and detecting copy number variations through the deviation of fluorescent signal intensity between patient and normal reference. Two major disadvantages of this setup are (1) the use of half of the resources to measure a (little informative) reference sample and (2) the possibility that deviating signals are caused by benign copy number variation in the “normal” reference instead of a pat

ORGANISM(S): Homo sapiens

SUBMITTER: Joris Vermeesch 

PROVIDER: E-GEOD-6538 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress