Dataset Information


Gene expression profiling of rheumatoid arthritis synovial tissues

ABSTRACT: Spots were selected that had an expression level higher than 1.6 the local background. The use of a common reference sample allows the comparison of the relative expression levels across the tissue samples. All genes were expressed relative to their median expression level across the arrays of the same microarray platform, allowing us to combine the data from the 2 platforms. Data from Lymphochip and Stanford Human cDNA arrays was combined per patient. Only genes with reliable datapoints in at least 80% of the samples were used. Subsequently, genes with the same unigene identifier were averaged in SMD. For all further analysis genes were selected that showed at least a two-fold difference in expression level in at least one array. A disease state experiment design type is where the state of some disease such as infection, pathology, syndrome, etc is studied. Using regression correlation

ORGANISM(S): Homo sapiens

SUBMITTER: Cornelis Verweij 

PROVIDER: E-GEOD-9027 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Inflammation and ectopic lymphoid structures in rheumatoid arthritis synovial tissues dissected by genomics technology: identification of the interleukin-7 signaling pathway in tissues with lymphoid neogenesis.

Timmer Trieneke C G TC   Baltus Belinda B   Vondenhoff Mark M   Huizinga Tom W J TW   Tak Paul P PP   Verweij Cornelis L CL   Mebius Reina E RE   van der Pouw Kraan Tineke C T M TC  

Arthritis and rheumatism 20070801 8

<h4>Objective</h4>In approximately 25% of synovial tissues from rheumatoid arthritis (RA) patients, infiltrates of T cells, B cells, and follicular dendritic cells (FDCs) are spatially organized into structures resembling lymph nodes with germinal centers. The remainder of the tissues lack FDCs and show either a diffuse or an aggregated T cell and B cell infiltrate. To gain more insight into this specific disease process, we sought to identify the genes expressed in RA tissues with ectopic lymph  ...[more]

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