Kawasaki Disease and Other Febrile Illnesses

ABSTRACT: ABSTRACT Background. Acute Kawasaki disease (KD) is difficult to distinguish from other acute rash/fever illnesses, in part because the etiologic agent(s) and pathophysiology remain poorly characterized. As a result, diagnosis and critical therapies may be delayed. Methods. We used DNA microarrays to identify possible diagnostic features of KD. We compared gene expression patterns in the blood of 23 children with acute KD and 18 age-matched febrile children with three illnesses that resemble KD. Results. Genes associated with platelet and neutrophil activation were expressed at higher levels in KD patients than in patients with acute adenovirus infections or systemic adverse drug reactions but not in patients with scarlet fever; genes associated with B cell activation were also expre

ORGANISM(S): Homo sapiens

SUBMITTER: Stephen Popper 

PROVIDER: E-GEOD-15297 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress