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ProteomicsTargetSeeker-MS: A Bayesian Inference Approach for Drug Target Discovery using Protein Fractionation Coupled to Mass Spectrometry
Determining the affinity of a drug to its putative targets is critical to the understanding of its mechanism and to assess its clinical usefulness and viability. Energetics-based protein separation (EBPS) techniques, such as thermal shift assay, when coupled to mass spectrometry (MS) have shown grea...
ORGANISM(S): Homo sapiens (Human) Caenorhabditis elegans 
2026-04-06 | PXD010799 | Pride
Bioinformatics / drug target discovery / mass spectrometry / proteomics / thermal shift assay 
ProteomicsFunction of the MYND domain and C-terminal region in regulating the subcellular localization and catalytic activity of the SMYD family lysine methyltransferase Set5
SMYD lysine methyltransferases target histones and non-histone proteins for methylation and are critical regulators of muscle developmental and implicated in neoplastic transformation. They are characterized by a split catalytic SET domain and an intervening MYND zinc finger domain, as well as an ex...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2019-11-11 | PXD014756 | Pride
Methyltransferase Saccharomyces cerevisiae 
ProteomicsEssential requirement for IER3IP1 in B cell development
In a forward genetic screen of mice with N-ethyl-N-nitrosourea (ENU)-induced mutations for aberrant immune function, we identified animals with low percentages of B220+ cells in the peripheral blood. The causative mutation was in Ier3ip1, encoding immediate early response 3 interacting protein 1 (IE...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-01-09 | MSV000091025 | MassIVE
ProteomicsTrans-Golgi protein TVP23B regulates host-microbe interactions via Paneth cell homeostasis and Goblet cell glycosylation
A key feature in intestinal immunity is the dynamic intestinal barrier, which separates the host from resident and pathogenic microbiota through a mucus gel impregnated with antimicrobial peptides. The mechanisms underlying the maintenance and function of this intestinal barrier are not completely ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-12-12 | MSV000090883 | MassIVE
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