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TranscriptomicsGenome-wide analysis of the miR profile in human head and neck paraganglioma vs. Jacobson's (tympanic) nerve and SH-SY5Y neuroblastoma cells
The aim of the study was to assess whether changes in the expression of miRs could be implicated in the modulation of the NOTCH pathway in head and neck paragangliomas. Several miRs, notably including families (miR-34s, miR-200s) that target the NOTCH signaling pathway, resulted differentially expre...
ORGANISM(S): Homo sapiens 
2013-08-21 | E-GEOD-49190 | biostudies-arrayexpress
TranscriptomicsHigh-density genome-wide copy number variation (CNV) in human head and neck paragangliomas.
Gene-centric CNV analysis of 24 individual paraganglioma cases identified a list of 104 genes most significantly targeted by tumor-associated alterations. The NOTCH signaling pathway was the most significantly enriched term in the list. Overexpression of the relevant NOTCH pathway proteins in susten...
ORGANISM(S): Homo sapiens 
2013-08-21 | E-GEOD-49614 | biostudies-arrayexpress
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