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TranscriptomicsEukaryote-Specific Insertion Elements Control Human ARGONAUTE Slicer Activity
We solved the crystal structure of human ARGONAUTE1 (hAGO1) bound to endogenous 5'-phosphorylated guide RNAs. To identify structural changes that evolutionarily rendered hAGO1 inactive, we compared our structure with published structures of guide-RNA-containing and cleavage-active hAGO2. Aside from ...
ORGANISM(S): Trichoplusia ni 
2013-06-20 | E-GEOD-48076 | biostudies-arrayexpress
TranscriptomicsMicroRNA sequence and expression analysis in breast tumors by deep sequencing
This SuperSeries is composed of the following subset Series: GSE29173: MicroRNA sequence and expression analysis in breast tumors by deep sequencing [miRNA sequence data] GSE29174: MicroRNA sequence and expression analysis in breast tumors by deep sequencing [mRNA expression array data] MicroRNAs (m...
ORGANISM(S): Homo sapiens 
2011-06-07 | E-GEOD-28884 | biostudies-arrayexpress
TranscriptomicsMicroRNA sequence and expression analysis in breast tumors by deep sequencing [miRNA sequence data]
MicroRNAs (miRNAs) regulate many genes critical for tumorigenesis. We profiled miRNAs from 11 normal breast tissues, 17 non-invasive, 151 invasive breast carcinomas, and 6 cell lines by in-house-developed barcoded Solexa sequencing. miRNAs were organized in genomic clusters representing promoter-con...
ORGANISM(S): Homo sapiens 
2011-06-06 | E-GEOD-29173 | biostudies-arrayexpress
TranscriptomicsMicroRNA sequence and expression analysis in breast tumors by deep sequencing [mRNA expression array data]
MicroRNAs (miRNAs) regulate many genes critical for tumorigenesis. We profiled miRNAs from 11 normal breast tissues, 17 non-invasive, 151 invasive breast carcinomas, and 6 cell lines by in-house-developed barcoded Solexa sequencing. miRNAs were organized in genomic clusters representing promoter-con...
ORGANISM(S): Homo sapiens 
2011-06-07 | E-GEOD-29174 | biostudies-arrayexpress
TranscriptomicsMulticolor miRNA fluorescence in situ hybridization for tumor differential diagnosis
We profiled and quantitated miRNAs in two skin tumors (Basal cell carcinoma and Merkel cell carcinoma) and identified tumor-specific miRNAs. We used these tumor-specific miRNAs to guide development of miRNA fluorescence in situ hybridization. 2 barcoded sequencing runs, including 40 unique samples (...
ORGANISM(S): Homo sapiens 
2013-06-28 | E-GEOD-34137 | biostudies-arrayexpress
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