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TranscriptomicsAMPK agonist AICAR improves cognition and motor coordination in young and aged mice
Normal aging can result in a decline of memory and muscle function. Exercise may prevent or delay these changes. However, aging associated frailty may preclude physical activity. AMP-activated protein kinase (AMPK) is a transcriptional regulator important for muscle physiology. In the present study...
ORGANISM(S): Mus musculus 
2014-01-17 | E-GEOD-50873 | biostudies-arrayexpress
ProteomicsSystems toxicological assessment of the mentholated Tobacco Heating System 2.2 product revealed reduced cellular and molecular exposure effects compared to cigarette smoke [quantitative proteomics of lung tissue]
Aiming to reduce smoking-related health risks, potential reduced risk products (pRRPs) are being developed. The Tobacco Heating System (THS) 2.2 is a recently developed pRRP, which utilizes the heat-not-burn principle. In this study, systems toxicology approaches were engaged to assess the respirato...
ORGANISM(S): Rattus norvegicus (Rat) 
2016-12-12 | PXD003580 | Pride
Reduced risk tobacco product  systems toxicology  rat inhalation study  itraq 
ProteomicsSystems toxicological assessment of the mentholated Tobacco Heating System 2.2 product revealed reduced cellular and molecular exposure effects compared to cigarette smoke [quantitative proteomics of rat nasal epithelium]
Aiming to reduce smoking-related health risks, potential reduced risk products (pRRPs) are being developed. The Tobacco Heating System (THS) 2.2 is a recently developed pRRP, which utilizes the heat-not-burn principle. In this study, systems toxicology approaches were engaged to assess the respirato...
ORGANISM(S): Rattus norvegicus (Rat) 
2016-12-13 | PXD003591 | Pride
Reduced risk tobacco product  systems toxicology  rat inhalation study  itraq 
UnknownElectronic Cigarette Vape Exposure Exacerbates Post-Ischemic Outcomes in Female but Not in Male Rats.
Not available
S-EPMC10940219 | biostudies-literature
TranscriptomicsAutotaxin and its product lysophosphatidic acid suppress brown adipose differentiation and promote diet-induced obesity in mice
Brown adipose tissue (BAT) is a thermogenic organ that dissipates stored energy as heat to maintain body temperature in infants and small mammals. This process may also provide protection from development of diet-induced obesity. We found that the bioactive lipid mediator lysophosphatidic acid (LP...
ORGANISM(S): Mus musculus 
2011-06-01 | E-GEOD-26442 | biostudies-arrayexpress
UnknownStroke promotes the development of brain atrophy and delayed cell death in hypertensive rats.
Not available
S-EPMC7678843 | biostudies-literature
UnknownNew fossil remains of Homo naledi from the Lesedi Chamber, South Africa.
Not available
S-EPMC5423776 | biostudies-literature
UnknownTissue Tropism of SV40 Transformation of Human Cells: Role of the Viral Regulatory Region and of Cellular Oncogenes.
Not available
S-EPMC3092263 | biostudies-literature
ProteomicsMitochondrial DNA affects tau expression and phosphorylation in Alzheimers Disease and aging in humans and cybrid cell lines
We investigate the role of mitochondrial DNA in Alzheimers Disease pathology using human cybrid cell lines and investigate the relationships between biomarker expression from cybrids and clinically relevant outcomes from the same individuals. Proteomic analysis of cybrids showed significant alterati...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-10-11 | MSV000096065 | MassIVE
UnknownInvestigating palygorskite's role in the development of mesothelioma in southern Nevada: Insights into fiber-induced carcinogenicity.
Not available
S-EPMC5062041 | biostudies-literature
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