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UnknownAdvancing the understanding of alveolar regeneration: Global research trends, thematic evolution, and emerging frontiers.
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S-EPMC12513304 | biostudies-literature
TranscriptomicsFunctional Roles of Hdac1/2 in lung development
Hdac1/2 are important epigenetic factors, yet their functional roles in specific tissues inluding lung is not determined. We used the conditional knockout model of Hdac1/2 to determine their roles in lung development. To explore the genes that are regulated by Hdac1/2 during lung development, we per...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-39946 | biostudies-arrayexpress
TranscriptomicsPromotion of Lung Tumorigenesis By Beta-catenin
Although mutations in Kras are present in 21% of lung tumors, there is a high level of heterogeneity in phenotype and outcomes amongst lung cancer patients suggesting the importance of other pathways. Wnt/β-catenin signaling is a known oncogenic pathway that plays a well defined role in colon and sk...
ORGANISM(S): Mus musculus 
2011-01-28 | E-GEOD-26850 | biostudies-arrayexpress
TranscriptomicsExpression data from Ezh2 epithelial knock-out mouse lungs at E14.5
Ezh2 epigenetically suppresses developmentally-regulated genes. Ezh2 is highly expressed during development, including in the lung. We knocked out Ezh2 in the developing lung epithelium using a Shh-cre driver which is active in foregut endoderm prior to lung morphogenesis. Many developmentally regul...
ORGANISM(S): Mus musculus 
2015-02-04 | E-GEOD-60660 | biostudies-arrayexpress
GenomicsMus musculus
Role of Fzd2 in lung epithelium development
PRJNA213735 | ENA
TranscriptomicsLong noncoding RNAs are spatially correlated with transcription factors and regulate lung development
To identify potential biological functions for three lncRNAs (NANCI, LL12, and LL34) we used shRNAs to knockdown expression of lncRNAs in MLE12 cells, a cell resembling type two lung epithelial cells. This data set contains the microarrays looking at gene expression. We used biological triplicate fo...
ORGANISM(S): Mus musculus 
2014-07-22 | E-GEOD-52389 | biostudies-arrayexpress
TranscriptomicsThe role of Foxp1/4 in lung development
Foxp1/4 transcription factors are conserved transcriptional repressors expressed in overlapping patterns during lung development as well as in the adult lung. However, the role of Foxp1/4 in development and homeostasis of the pseudostratified epithelium of the proximal airways and trachea is unknown...
ORGANISM(S): Mus musculus 
2012-08-01 | E-GEOD-34584 | biostudies-arrayexpress
GenomicNextGen Consortium: iPS Derived Hepatocytes Study (PhLiPS Study)

The goal of the PhLiPS study is to create a library of induced pluripotent stem cell (iPSC) lines and iPSC-derived hepatocytes of diverse genotypes for use in metabolic profiling and interrogating lipid phenotypes. These cell lines were created as a part of the Next Generation Genetic Association...

phs001341 | dbGaP
TranscriptomicsmiR-302-367 regulates cardiomycyte proliferation and differentiation during development
To define the role of miR-302-367 cluster in cardiac development, we overexpressed miR-302-367 cluster in mouse heart by using R26R-miR-302-367; Nkx2.5-Cre mice. This data set contains the microarrays examining gene expression in the hearts of R26R-miR-302-367; Nkx2.5-Cre mice at postnatal day 14. W...
ORGANISM(S): Mus musculus 
2015-01-01 | E-GEOD-54988 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human ischemic cardiomyopathy, idiopathic cardiomyopathy, and nonfailing controls
Left ventricular myocardium was snap-frozen at time of cardiac transplantation from patients with advanced idiopathic or ischemic cardiomyopathy, or at time of harvest from unused donor heart that serve as a nonfailing control. No subjects received mechanical support devices. Experiment Overall Des...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-5406 | biostudies-arrayexpress
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