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TranscriptomicsThe Polycomb Group Protein Bmi-1 is essential for the growth of Multiple Myeloma cells
The RPMI-8226 human multiple myeloma cell line was stably infected with either a validated shRNA against BMI1 or a control shRNA. RNA was prepared from these lines, +/- doxycycline induction and at various time points post-induction. Samples were hybridized on the Affymetrix U133plus2 human genome...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-GEOD-21912 | biostudies-arrayexpress
UnknownDensity Functional Theory-Based Calculation Shed New Light on the Bizarre Addition of Cysteine Thiol to Dopaquinone.
Not available
S-EPMC7866380 | biostudies-literature
UnknownBaseline α-synuclein seeding activity and disease progression in sporadic and genetic Parkinson's disease in the PPMI cohort.
Not available
S-EPMC12354789 | biostudies-literature
TranscriptomicsDivergent functions of hematopoietic transcription factors in lineage priming and differentiation during erythro-megakaryopoiesis
Combinatorial actions of relatively few transcription factors control hematopoietic differentiation. To investigate this process in erythro-megakaryopoiesis, we correlated the genome-wide chromatin occupancy signatures of four master hematopoietic transcription factors (GATA1, GATA2, SCL/TAL1 and FL...
ORGANISM(S): Mus musculus 
2013-08-09 | E-GEOD-49664 | biostudies-arrayexpress
TranscriptomicsDivergent functions of hematopoietic transcription factors in lineage priming and differentiation during erythro-megakaryopoiesis
Combinatorial actions of relatively few transcription factors control hematopoietic differentiation. To investigate this process in erythro-megakaryopoiesis, we correlated the genome-wide chromatin occupancy signatures of four master hematopoietic transcription factors (GATA1, GATA2, TAL1, and FLI1)...
ORGANISM(S): Mus musculus 
2014-11-14 | E-GEOD-51337 | biostudies-arrayexpress
TranscriptomicsCells Comprising the Prostate Cancer Microenvironment Lack Recurrent Clonal Somatic Genomic Aberrations
Prostate cancer-associated stroma (CAS) plays an active role in malignant transformation, tumor progression, and metastasis. Molecular analyses of CAS have demonstrated significant changes in gene expression; however, conflicting evidence exists on whether genomic alterations in benign cells compris...
ORGANISM(S): Homo sapiens 
2016-02-12 | E-GEOD-76456 | biostudies-arrayexpress
UnknownCells Comprising the Prostate Cancer Microenvironment Lack Recurrent Clonal Somatic Genomic Aberrations.
Not available
S-EPMC5582956 | biostudies-literature
Genomicsena-DATASET-BCCA-06-12-2013-17:57:13:627-21 - samples
Complete set of bam files associated with study EGAS00001000622
EGAD00001000702 | EGA
GenomicsPharmacological and genomic profiling identifies NFκB-targeted treatment strategies for mantle cell lymphoma
Mantle cell lymphoma (MCL) is an aggressive malignancy characterized by poor prognosis, underscoring the need for novel therapeutic strategies1. In this study, we employed large-scale pharmacological profiling of 16 pathway inhibitors across more than 100 hematological cell line models to identify n...
EGAS00001000622 | EGA
TranscriptomicsMetabolic switching in Streptomyces coelicolor Timeseries 1
Background: During the lifetime of a fermenter culture, the soil bacterium S. coelicolor undergoes a major metabolic switch from exponential growth to antibiotic production. We have studied gene expression patterns during this switch, using a specifically designed Affymetrix genechip and a high-reso...
ORGANISM(S): Streptomyces coelicolor 
2010-05-18 | E-GEOD-18489 | biostudies-arrayexpress
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