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Transcriptomicsm1A marks translation initiation sites in human and mouse messenger RNA
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2016-02-12 | E-GEOD-76058 | biostudies-arrayexpress
TranscriptomicsTopology of the human and mouse m6A RNA methylomes revealed by m6A-seq
This SuperSeries is composed of the following subset Series: GSE36958: Gene expression profiles of WT and ime4-/- mutant yeast cells, under vegetative and meiosis-inducing conditions GSE37001: METTL3 KD in HepG2 cells GSE37002: m6A mapping in human RNA (with treatments) GSE37003: m6A mapping in huma...
ORGANISM(S): Saccharomyces cerevisiae 
2012-04-24 | E-GEOD-37005 | biostudies-arrayexpress
Transcriptomicsm6A mapping in human RNA (untreated)
We developed a novel approach, m6A-seq, for high-resolution mapping of the transcriptome-wide m6A landscape, based on antibody-mediated capture followed by massively parallel sequencing. Identification of m6A modified sequences in HepG2 cells.
ORGANISM(S): Homo sapiens 
2012-04-25 | E-GEOD-37003 | biostudies-arrayexpress
Transcriptomicsm1A marks translation initiation sites in human and mouse messenger RNA [Sequencing]
We developed a novel approach, m1A-seq, for high-resolution mapping of the transcriptome-wide m1A landscape, based on antibody-mediated capture followed by massively parallel sequencing Identification of m1A modified sequences in human, mouse and yeast cell lines
ORGANISM(S): Homo sapiens 
2016-02-10 | E-GEOD-70485 | biostudies-arrayexpress
Transcriptomicsm1A marks translation initiation sites in human and mouse messenger RNA [microarray]
We developed a novel approach, m1A-seq, for high-resolution mapping of the transcriptome-wide m1A landscape, based on antibody-mediated capture followed by massively parallel sequencing. Using this method we performed immunodepletion of methylated transcipts to assess the average methylation level I...
ORGANISM(S): Homo sapiens 
2016-02-12 | E-GEOD-76057 | biostudies-arrayexpress
Transcriptomicsm6A mapping in human RNA (with treatments)
We developed a novel approach, m6A-seq, for high-resolution mapping of the transcriptome-wide m6A landscape, based on antibody-mediated capture followed by massively parallel sequencing. Identification of m6A modified sequences in HepG2 cells. HepG2 cells were incubated with either IFNg (200ng/ml) o...
ORGANISM(S): Homo sapiens 
2012-04-25 | E-GEOD-37002 | biostudies-arrayexpress
Transcriptomicsm6A RNA Methylation is Critical for Adequate Exit from Naïve Pluripotency and Execution of Mammalian Development (RNA-Seq)
In this study we identify Mettl3, an m6A RNA modification writer, as a critical regulator for terminating naïve pluripotency and a positive maintainer of primed pluripotency in vitro and in vivo. Remarkably, Mettl3 knockout pre-implantation epiblasts and naïve ES cells, entirely lack m6A on coding m...
ORGANISM(S): Mus musculus 
2014-11-02 | E-GEOD-61997 | biostudies-arrayexpress
Transcriptomicsm6A RNA Methylation is Critical for Adequate Exit from NaM-CM-/ve Pluripotency and Execution of Mammalian Development (3p-Seq)
In this study we identify Mettl3, an m6A RNA modification writer, as a critical regulator for terminating naM-CM-/ve pluripotency and a positive maintainer of primed pluripotency in vitro and in vivo. Remarkably, Mettl3 knockout pre-implantation epiblasts and naM-CM-/ve ES cells, entirely lack m6A o...
ORGANISM(S): Mus musculus 
2014-11-02 | E-GEOD-61994 | biostudies-arrayexpress
Transcriptomicsm6A RNA Methylation is Critical for Adequate Exit from NaM-CM-/ve Pluripotency and Execution of Mammalian Development (m6a-seq)
In this study we identify Mettl3, an m6A RNA modification writer, as a critical regulator for terminating naM-CM-/ve pluripotency and a positive maintainer of primed pluripotency in vitro and in vivo. Remarkably, Mettl3 knockout pre-implantation epiblasts and naM-CM-/ve ES cells, entirely lack m6A o...
ORGANISM(S): Mus musculus 
2014-11-02 | E-GEOD-61995 | biostudies-arrayexpress
Transcriptomicsm6A RNA Methylation is Critical for Adequate Exit from Naïve Pluripotency and Execution of Mammalian Development (Ribo-seq)
In this study we identify Mettl3, an m6A RNA modification writer, as a critical regulator for terminating naïve pluripotency and a positive maintainer of primed pluripotency in vitro and in vivo. Remarkably, Mettl3 knockout pre-implantation epiblasts and naïve ES cells, entirely lack m6A on coding m...
ORGANISM(S): Mus musculus 
2014-11-02 | E-GEOD-61996 | biostudies-arrayexpress
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