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TranscriptomicsThe transcriptomic signature of myostatin inhibitory influence on the differentiation of mouse C2C12 myoblasts
GDF8 (myostatin) is a unique cytokine strongly affecting the skeletal muscle phenotype in human and animals. The aim of the present study was to elucidate the molecular mechanism of myostatin influence on the differentiation of mouse C2C12 myoblasts, using the global-transcriptome analysis with the ...
ORGANISM(S): Mus musculus 
2014-07-23 | E-GEOD-59674 | biostudies-arrayexpress
TranscriptomicsTranscriptional analysis of follistatin influence on C2C12 mice myoblasts differentiation
Background: Follistatin (FS) is an activin-binding glycoprotein, known for its antagonistic action on the TGF-M-NM-2 super-family of cytokines. It has ability to prevent muscle atrophy and to stimulate muscle growth through binding of myostatin (GDF8). FS does not cause these changes only by inhibit...
ORGANISM(S): Mus musculus 
2014-10-31 | E-GEOD-59775 | biostudies-arrayexpress
TranscriptomicsCharacteristics of microRNA expression in mammary tissue of dairy and beef breed heifers
MicroRNAs (miRNAs) are small noncoding RNAs that participate in regulation of gene expression. Their role during mammary gland development is still largely unknown. In the present study, we performed a microarray analysis to identify miRNAs associated with high mammogenic potential of bovine mammary...
ORGANISM(S): Bos taurus 
2014-09-15 | E-GEOD-61227 | biostudies-arrayexpress
TranscriptomicsComparison of stem/progenitor cell number and transcriptomic profile in mammary tissue of dairy and beef breed heifers
Bovine mammary stem cells (MaSC) are a source of ductal and lobulo-alveolar tissue during development of mammary gland and its remodeling in repeating lactation cycles. We hypothesize that the number of MaSC, their molecular properties and interactions with their niche may be essential to determine ...
ORGANISM(S): Bos taurus 
2013-06-16 | E-GEOD-47816 | biostudies-arrayexpress
TranscriptomicsGene expression profile of cancer cells and macrophages growing as a co-culture
Molecular mechanisms of the cancer cells-macrophages interactions growing in vitro conditions as a co-culture. The five canine mammary cancer cell lines were cultured with monocytes sorted from the canine blood for 72hrs. Then, the cancer cells and macrophages were sorted and the gene expression ana...
ORGANISM(S): Canis lupus familiaris 
2012-05-30 | E-GEOD-29339 | biostudies-arrayexpress
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