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MetabolomicsMetabolomic analysis of mouse embryonic fibroblasts, embryonic stem cells, and induced pluripotent stem cells
Not available
ORGANISM(S): Mus musculus 
ST000003 | MetabolomicsWorkbench
MetabolomicsPFKFB3-mediated glycolysis boosts fibroblast activation and subsequent kidney fibrosis

Renal fibrosis, a hallmark of chronic kidney diseases, is driven by the activation of renal fibroblasts. Recent studies have highlighted the role of glycolysis in this process. Nevertheless, one critical glycolytic activator, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3), remain...

2024-03-12 | MTBLS8281 | MetaboLights
MetabolomicsGut Microbiota-Proline Axis Drives HFpEF Through Fibroblast Ferroptosis

Heart failure with preserved ejection fraction (HFpEF) is a complex cardiometabolic disorder closely associated with systemic metabolic dysregulation. In this study, plasma samples were collected from C57BL/6J mice subjected to a high-fat diet–induced HFpEF model, with or without intervention, an...

2026-01-16 | MTBLS13700 | MetaboLights
MetabolomicsQuantification of PIPs species in mouse embryonic fibroblasts (MEFs) during autophagosome formation.
Not available
ORGANISM(S): Mus musculus 
ST001818 | MetabolomicsWorkbench
MetabolomicsQuantification of PIPs species in LPIAT1 KO mouse embryonic fibroblasts (MEFs).
Not available
ORGANISM(S): Mus musculus 
ST001817 | MetabolomicsWorkbench
TranscriptomicsTranscription profiling of mouse embryonic fibroblast cultures - induction of pluripotent-like cells derived from MEF by defined factors
Differentiated cells can be reprogrammed to an embryonic-like state by transfer of their nuclear contents into oocytes or by fusion with embryonic stem (ES) cells. Little is known about the factors that induce this reprogramming. Here we show that the combination of four factors, Oct3/4, Sox2, c-Myc...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-5259 | biostudies-arrayexpress
TranscriptomicsFGF2 stimulation experiment with NMRI mouse embryonic fibroblasts
Mouse embryonic fibroblasts stimulated with 40 ng/ml of FGF2 in conventional hES cell medium were analysed on whole-genome expression chips to reveal altered expression of genes encoding secreted proteins. as detailed for the individual samples
ORGANISM(S): Mus musculus 
2010-06-10 | E-GEOD-5436 | biostudies-arrayexpress
TranscriptomicsFGF2 stimulation experiment with CD1 mouse embryonic fibroblasts
Mouse embryonic fibroblasts stimulated with 40 ng/ml of FGF2 in conventional hES cell medium were analysed on whole-genome expression chips to reveal altered expression of genes encoding secreted proteins. as detailed for the individual samples
ORGANISM(S): Mus musculus 
2010-06-10 | E-GEOD-5435 | biostudies-arrayexpress
ProteomicsHuman Epididymis Protein 4 Promotes Aberrant Epithelial-Fibroblast Crosstalk in Pulmonary Fibrosis
Invasive lung myofibroblasts are the main cause of tissue remodeling in idiopathic pulmonary fibrosis (IPF). A key mechanism contributing to this important feature is aberrant crosstalk between the abnormal/injured lung epithelium and pulmonary fibroblasts. Here, we demonstrated that lungs from pati...
ORGANISM(S): Homo Sapiens 
2024-12-17 | PXD058959 |
ProteomicsFibroblast-derived Smoothened governs prognosis of acute kidney injury
Although the tubule is the epicenter of damage, kidney fibroblast is increasingly appreciated in governing the prognosis of acute kidney injury (AKI). Smoothened (Smo), a heptahelical transmembrane protein, carries a hedgehog signal to mediate the communications between kidney fibroblasts and tubula...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2021-12-23 | MSV000088609 | MassIVE
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