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TranscriptomicsDNA damage signaling gene array on SMA mouse skeletal muscle
A commercially available gene array (SABiosciences array PAMM-029ZD-12) was used to assay gene expression in skeletal muscle of SMA mice and control littermates. The Taiwanese severe SMA mouse model was used (Hsieh-Li et al. 2000). The array included 84 genes associated with DNA damage detection, DN...
ORGANISM(S): Mus musculus 
2014-03-03 | E-GEOD-55481 | biostudies-arrayexpress
TranscriptomicsMicroarrays of mouse embryonic limb skeletal muscle at days E14.5 and E18.5 lacking the RYR1 or Cav1.1 Ca2+ channels
Our aim is to analyze how does the lack of each of the Ca2+ channels, involved in excitation-contraction coupling in skeletal muscle - RYR1 and Cav1.1, affect gene expression in embryonic mouse limb skeletal muscle during secondary myogenesis. We extracted total RNA from the limb skeletal muscle of ...
ORGANISM(S): Mus musculus 
2017-11-24 | E-MTAB-5755 | biostudies-arrayexpress
TranscriptomicsMyocardin-related Transcription Factors Are Required for Skeletal Muscle Development
Myocardin-related transcription factors (MRTFs) play a central role in the regulation of actin expression and cytoskeletal dynamics. Stimuli that promote actin polymerization allow for shuttling of MRTFs to the nucleus where they activate serum response factor (SRF), a regulator of actin and other c...
ORGANISM(S): Mus musculus 
2016-08-02 | E-GEOD-84063 | biostudies-arrayexpress
TranscriptomicsNeurofibromin (Nf1) is required for skeletal muscle development
Neurofibromatosis type 1 (NF1) is a multi-system disease caused by mutations in the NF1 gene encoding a Ras-GAP protein, neurofibromin, which negatively regulates Ras signalling. Besides neuroectodermal malformations and tumours, the skeletal system is often affected (e.g. scoliosis and long bone dy...
ORGANISM(S): Mus musculus 
2011-05-18 | E-GEOD-29343 | biostudies-arrayexpress
GenomicsGenome-wide mapping of Sox6 binding sites in mouse fetal myotubes
In order to understand how Sox6 coordinately regulates the transcription of multiple fiber type specific genes during muscle development, we have performed ChIP-seq analyses to identify Sox6 target genes as well as RNA polymerase II (Pol II) binding sites in mouse fetal myotubes. Examinat...
ORGANISM(S): Mus musculus 
2011-10-06 | E-GEOD-32627 | biostudies-arrayexpress
TranscriptomicsDysregulated gene expression in Mef2a knockout mice subjected to cardiotoxin-induced muscle injury
We identified genes expressed in mouse skeletal muscle, during the process of muscle regeneration after injury, which are dysregulated in the absence of Mef2a expression. MEF2A is a member of the evolutionarily conserved MEF2 transcription factor family which has known roles in cardiac muscle develo...
ORGANISM(S): Mus musculus 
2013-02-12 | E-GEOD-41871 | biostudies-arrayexpress
ProteomicsIntrauterine hyperglycemia during late gestation caused mitochondrial dysfunction in skeletal muscle of male offspring through CREB/PGC1A signaling
Short-term intrauterine hyperglycaemia significantly reduced lean mass in male offspring at 8 weeks, resulting in decreased exercise endurance and metabolic disorders. Disrupted organization and function of the mitochondria in skeletal muscle were also observed among them. Foetal exposure to hypergl...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-09 | PXD049987 | Pride
Mouse embryonic skeletal muscle in limb 
TranscriptomicsTranscription profiling of mouse masticatory and limb skeletal muscle
Distinctions between craniofacial and axial muscles exist from the onset of development and throughout adulthood. The masticatory muscles are a specialized group of craniofacial muscles that retain embryonic fiber properties throughout adulthood, suggesting that the developmental origin of these mus...
ORGANISM(S): Mus musculus 
2008-06-20 | E-GEOD-11114 | biostudies-arrayexpress
TranscriptomicsTranscriptional analysis of genes regulating the mitochondrial dNTP pool in muscle cells.
Mutations in genes involved in dNTP metabolism can lead to tissue-specific mitochondrial depletion syndromes (MDS), likely because the expression of key enzymes is reduced to critical levels in post mitotic cells. Our goal was to establish an in vitro skeletal muscle cell model to study the muscle s...
ORGANISM(S): Mus musculus 
2013-03-08 | E-GEOD-41877 | biostudies-arrayexpress
TranscriptomicsExpression data from Lbx1-EGFP+ flow sorted cells from Pitx2 WT, HT, Null forelimb tissue
Determing the gene network regulated by Pitx2 in during forelimb muscle development of mouse embryos at E12.5. Lbx1 is coexpressed in Pitx2+ cells during forelimb development, thus Pitx2-LacZ and Lbx1-EGFP+ mice were cross bred to allow us to purify Lbx1-EGFP+|Pitx2 -wild type, het, or null cells b...
ORGANISM(S): Mus musculus 
2013-06-11 | E-GEOD-31945 | biostudies-arrayexpress
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