Mouse heart mitochondria mutator mtdna

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Proteomics (3)
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pride (2)
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Transcription profiling by array (1)

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Max Planck Institute of Biochemistry, Dept. Proteomics and Signal Transduction, Martinsried, Germany (1)
Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki; Helsinki, Finland. (1)

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Subcellular proteomics combined with bioenergetic phenotyping reveals protein biomarkers of respiratory insufficiency in the setting of compromised mitochondrial DNA repair.

The mitochondrial mutator mouse is a well-established model of premature aging in which a progeroid phenotype is driven by the accumulation of somatic mtDNA mutations. Despite evidence of bioenergetic disruption within the cardiac mitochondria, there is little information about the underlying change...

ORGANISM(S): Mus Musculus (mouse)

2021-01-08 | PXD017000 | JPOST Repository

Cardiomyocyte-intrinsic somatic mtDNA mutations induce an OXPHOS-dependent immune response and promote progressive heart failure

Mitochondrial DNA (mtDNA) mutations accumulate with age, but their mechanistic contribution to ageing remains unclear. The classical mtDNA mutator mouse expresses a proofreading-deficient mtDNA polymerase (POLGD257A) and accumulates mtDNA mutations across all tissues leading to premature ageing. How...

ORGANISM(S): Mus musculus (Mouse)

2026-07-28 | PXD080411 | Pride

Exercise-induced mitochondrial translocation of p53 repairs mitochondrial DNA mutations

Exercise is a fundamental component of human health that is associated with greater life expectancy and reduced risk of chronic diseases. While the beneficial effects of endurance exercise on human health are well established, the molecular mechanisms responsible for these observations remain unclea...

ORGANISM(S): Mus musculus

2015-12-11 | E-GEOD-75869 | biostudies-arrayexpress

Bioenergetic consequences of compromised mitochondrial DNA repair in the mouse heart.

Not available

S-EPMC6173612 | biostudies-literature

Overactive mitochondrial DNA replication disrupts perinatal cardiac maturation

Proteomic analysis of the neonatal hearts of mice carrying an exonuclease-deficient DNA polymerase gamma and overexpressing Twinkle helicase. For further methodological details please refer to the associated original publication.