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Unknown (12398)
Genomics (4647)
Transcriptomics (3465)
Proteomics (515)
Metabolomics (72)
Other (66)
Methylation profiling (31)
Clinical (20)
Models (15)
Genomic (2)
Multiomics (1)

Organisms

Mus musculus (2795)
Homo sapiens (880)
Gallus gallus (85)
Rattus norvegicus (80)
Sus scrofa (52)
Danio rerio (29)
Oncorhynchus mykiss (25)
Salmo salar (21)
Bos taurus (16)
Macaca mulatta (16)
Gadus morhua (9)
Canis lupus familiaris (9)
Ovis aries (9)
Salmonella enterica subsp. enterica serovar Typhimurium (8)
Scophthalmus maximus (7)
Macaca fascicularis (7)
Mycobacterium tuberculosis (4)
Epinephelus coioides (4)
Marmota monax (4)
Leishmania donovani (4)
Equus caballus (4)
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Listeria monocytogenes EGD-e (2)
Castor canadensis (2)
Xenopus laevis (2)
Triticum aestivum (2)
Salmonella enterica subsp. enterica serovar Typhimurium str. DT104 (1)
Clostridioides difficile (1)
Pacifastacus leniusculus (1)
Mycobacterium tuberculosis variant bovis BCG (1)

Organisms

Mus musculus (2337)
Homo sapiens (240)
Gallus gallus (65)
Rattus norvegicus (53)
Sus scrofa (47)
Oncorhynchus mykiss (19)
Danio rerio (15)
Paralichthys olivaceus (13)
Salmo salar (12)
Oreochromis niloticus (11)
Macaca mulatta (11)
unidentified (11)
Bos taurus (8)
Infectious spleen and kidney necrosis virus (7)
Scophthalmus maximus (7)
Canis lupus familiaris (7)
Epinephelus coioides (6)
Macaca fascicularis (6)
Ctenopharyngodon idella (6)
Ictalurus punctatus (5)
Salmonella enterica subsp. enterica serovar Typhimurium (5)
mouse metagenome (5)
Triplophysa bleekeri (4)
Meleagris gallopavo (4)
Gadus morhua (4)
Lates calcarifer (4)
Equus caballus (4)
Ovis aries (4)
mouse gut metagenome (4)
Hemiscyllium ocellatum (3)

Repository

ENA (4092)
biostudies-arrayexpress (2076)
geo (1904)
pride (376)
EGA (93)
iProX (51)
ExpressionAtlas (42)
MassIVE (40)
MetaboLights (40)
NODE (21)
MetabolomicsWorkbench (19)
BioModels (13)
PAXDB (13)
jPOST (12)
PeptideAtlas (10)
GNPS (5)
GPMDB (3)
PanoramaPublic (3)
Cell Collective (2)
dbGaP (2)

Tissue

Spleen (331)
Liver (123)
Kidney (103)
Lung (100)
Heart (95)
Brain (80)
Testis (52)
Lymph node (46)
Colon (40)
Pancreas (34)
Bone marrow (29)
Ovary (26)
Stomach (24)
Small intestine (22)
Adrenal gland (19)
Thymus (16)
Duodenum (14)
Cerebellum (14)
Uterus (13)
Placenta (13)
Prostate gland (13)
Adipose tissue (12)
Thyroid gland (12)
Skeletal muscle tissue (11)
Tonsil (9)
Pituitary gland (8)
Cerebral cortex (7)
Epididymis (7)
Endometrium (5)
Zone of skin (5)

Disease

Normal (9)
Breast cancer (6)
Melanoma (3)
Rheumatoid arthritis (2)
Parkinson's disease (2)
Porphyria NOS (2)
Pancreatic ductal adenocarcinoma (2)
Allergy (1)
Nijmegen breakage syndrome (1)
Adenocarcinoma (1)
Adenomyosis (1)
Uterine fibroid (1)
Neuromuscular pain (1)
Endometriosis (1)
Prostate cancer (1)
Hepatocellular carcinoma (1)
Benign prostatic hyperplasia (1)
Primary bacterial infectious disease (1)
Tumor bearing (1)
Septic peritonitis (1)
MAS (1)
4T1 tumor-bearing (1)
Healthy donor (1)
B. dendrobatidis infection (1)
Erythroleukemia (1)
Infected (1)
Normal (control treated) (1)
Germ-free (1)
Mock infected (1)
Represent tolerant CD4+ T cells that have not been activated (1)

Technology Type

Mass Spectrometry (389)
Shotgun proteomics (215)
Bottom-up proteomics (71)
Affinity purification coupled with mass spectrometry proteomics (39)
Data-dependent acquisition (37)
Gel-based experiment (27)
Mass spectrometry (24)
Data-independent acquisition (22)
SWATH MS (19)
Top-down proteomics (14)
Mass spectrometry assay (13)
ESI (12)
NMR (6)
SRM/MRM (5)
Illumina HiSeq 2000 (4)
Illumina HiSeq 2500, ILLUMINA (3)
NMR spectroscopy (3)
Illumina HiSeq 2500 (2)
Mass spectrometry imaging (2)
DiaPASEF (2)
Combined on identical nucleotide universal identifier, Illumina HumanWG-6 version 3 or Illumina HumanHT-12 expression bead chip (1)
Illumina HiSeq 4000, ILLUMINA (1)
Perlegen, Affymetrix, Illumina (1)
AB SOLiD 4 System (1)
EI (1)
All-ion fragmentation (1)
HDMSE (1)
Chemical cross-linking coupled with mass spectrometry proteomics (1)

Instrument Platform

Illumina NovaSeq 6000 (75)
Illumina HiSeq 2500 (37)
NextSeq 500 (34)
Illumina HiSeq 2000 (33)
Illumina HiSeq 4000 (31)
Illumina MiSeq (14)
NextSeq 550 (12)
NextSeq 2000 (7)
Illumina HiSeq 1500 (6)
Flow Cytometer (4)
GeneChip Scanner 3000 7G (3)
G2565BA DNA microarray scanner [Agilent] (3)
Illumina NovaSeq X (3)
NA (3)
Thermomixer (2)
MouseWG-6_V2_0_R1_11278593_A (2)
454 GS FLX+ (2)
Agilent 2100 Bioanalyzer (2)
GenePix Professional 4200A [Axon Instruments] (2)
Axon GenePix 4000B scanning hardware (2)
Ion Torrent Proton (2)
DNBSEQ-G400 (2)
Illumina HiSeq 3000 (2)
TruSeq Stranded Total RNA kit (Illumina) (1)
NextSeq 500, 75 bp single end lane (1)
BD Rhapsody Express Instrument (1)
10X Genomics Single Cell, V3.1 (1)
BD FACSAria™ III (1)
GeneSpring (1)
GeneChip Scanner 3000 7G. Expression Console Software (ThermoFisher Scientific) (1)

Publication Date

2014 (344)
2013 (323)
2015 (303)
2026 (287)
2012 (280)
2021 (272)
2024 (252)
2023 (246)
2016 (241)
2010 (241)
2022 (239)
2025 (236)
2020 (226)
2011 (185)
2019 (181)
2008 (143)
2018 (142)
2017 (134)
2009 (113)
2003 (46)
2007 (44)
2005 (34)
2006 (30)
2004 (8)
2002 (2)
2001 (1)

UNIPROT ID/AC

Q75N73 (2)
Q9EQ21 (2)
Q921I1 (2)
Q16850 (2)
Q9BQG2 (2)
B3KXN9 (2)
Q53HM1 (2)
Q4FEB3 (2)
Q9HBF5 (2)
Q86SK9 (2)
E9KL42 (2)
Q3I5F7 (2)
P33897 (2)
Q99884 (2)
A8MU28 (2)
P35219 (2)
Q16698 (2)
Q5FC00 (2)
Q15274 (2)
Q9NX14 (2)
Q9Y345 (2)
Q86YT5 (2)
Q53H96 (2)
Q9NWU1 (2)
Q96C36 (2)
Q9NRX3 (2)
Q9UBF8 (2)
B4DYG5 (2)
P38571 (2)
O75610 (2)

ENSEMBL ID

ENSECAG00000006545 (3)
ENSECAG00000021065 (3)
ENSECAG00000012048 (3)
ENSECAG00000003601 (3)
ENSECAG00000024284 (3)
ENSECAG00000021241 (3)
ENSECAP00000014020 (3)
ENSECAG00000023592 (3)
ENSECAG00000023185 (3)
ENSECAG00000019677 (3)
ENSECAG00000019671 (3)
ENSECAG00000019192 (3)
ENSECAG00000016911 (3)
ENSECAG00000011670 (3)
ENSECAG00000004911 (3)
ENSECAG00000003079 (3)
ENSECAG00000014408 (3)
ENSECAG00000013962 (3)
ENSECAG00000013135 (3)
ENSECAG00000014872 (3)
ENSECAP00000015442 (3)
ENSECAG00000021478 (3)
ENSECAG00000000817 (3)
ENSECAG00000020501 (3)
ENSECAG00000019121 (3)
ENSECAG00000017026 (3)
ENSECAG00000016206 (3)
ENSECAG00000005471 (3)
ENSECAP00000019663 (3)
ENSECAP00000018729 (3)

CHEBI ID

CHEBI:30794 (5)
CHEBI:29034 (4)
CHEBI:28922 (3)
CHEBI:28852 (3)
CHEBI:34939 (3)
CHEBI:27696 (3)
CHEBI:27555 (3)
CHEBI:28099 (3)
CHEBI:27624 (3)
CHEBI:34306 (3)
CHEBI:3110 (3)
CHEBI:16565 (3)
CHEBI:16480 (3)
CHEBI:16382 (3)
CHEBI:27491 (3)
CHEBI:16987 (3)
CHEBI:17534 (3)
CHEBI:31997 (3)
CHEBI:28940 (3)
CHEBI:27647 (3)
CHEBI:16290 (3)
CHEBI:16313 (3)
CHEBI:17703 (3)
CHEBI:15355 (3)
CHEBI:32984 (3)
CHEBI:15750 (3)
CHEBI:15812 (3)
CHEBI:16478 (3)
CHEBI:16250 (3)
CHEBI:15876 (3)

Metabolite Name

Taurine (8)
Suberic acid (7)
Citric acid (6)
Glutaric acid (6)
Phthalic acid (5)
Xanthosine (5)
Arachidonic acid (5)
L-Glutamine (5)
Azelaic acid (5)
Guanosine (5)
Uridine (5)
Glucose (4)
Glycine (4)
Prostaglandin E2 (4)
Hydroxyphenyllactic acid (4)
Citrulline (4)
Allantoin (4)
4-Hydroxybenzoic acid (4)
L-Histidine (4)
Methionine (4)
Nonanoic acid (4)
Taurocholic acid (4)
Phenylacetylglycine (4)
Tyrosol (4)
Cholic acid (4)
Docosahexaenoic acid (4)
Stearic acid (4)
3-Hydroxybutyric acid (4)
Malic acid (4)
Tetradecanedioic acid (4)

First Public Date

2014 (510)
2024 (497)
2025 (449)
2023 (433)
2026 (431)
2022 (344)
2021 (326)
2020 (306)
2019 (222)
2018 (159)
2017 (147)
2015 (111)
2013 (77)
2016 (76)
2012 (2)
2011 (2)

Modelling Approach

Ordinary differential equation model (10)

Study status

Recruiting (11)
Not yet recruiting (6)
Withdrawn (2)
Not provided (1)

Lab affiliation

Institute of Pharmacology and Structural Biology, CNRS, Toulouse (6)
University of Alabama at Birmingham, O'Neal Mass Spectrometry Proteomics Shared Facility (4)
Department of Pharmaceutical Sciences, University of Illinois College of Pharmacy,Chicago,IL,USA Richard and Loan Hill Department of Biomedical Engineering, University of Illinois College of Engineering,Chicago, IL,USA University of Illinois Cancer Center,Chicago, IL,USA (3)
State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic & Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, China. (3)
Division of Cell Signalling and Immunology, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, Scotland, United Kingdom (3)
Division of Cell Signalling and Immunology, School of Life Sciences, University of Dundee, Dundee, UK (3)
Yale University (3)
Departments of Immunology and Radiation Oncology Moffitt Cancer Center Tampa, FL, USA (2)
1 Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Auguste-Piccard-Hof 1, 8093 Zurich, Switzerland 2 Faculty of Science, University of Zurich, Zurich, Switzerland (2)
CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences Lazarettgasse 14, AKH BT 25.3 1090 Vienna, Austria (2)
Crown Bioscience (2)
Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria, Australia. (2)
Unité de Parasitologie moléculaire et Signalisation, Institut Pasteur, Université de Paris, INSERM U1201, Paris 75015, France (2)
Lund University, Faculty of Medicine, Department of Clinical Sciences Lund, Division of Infection Medicine, Lund, Sweden (2)
Clinical Division of Fish Medicine, University of Veterinary Medicine, Vienna, Austria (2)
Department of Genetics, Cell Bioliogy, & Anatomy Buckley Lab University of Nebraska Medical Center Omaha, Nebraska United States of America (2)
Deputy Head (Research), Department of Biochemistry and Molecular Biology Head Immunoproteomics Laboratory Infection and Immunity Program Room 214, level 2, 15 Innovation Walk Monash Biomedicine Discovery Institute Monash University, Clayton Campus Clayton 3800 Victoria Australia (2)
Div. Clinical Protein Science & Imaging, Dept. of Clinical Sciences (Lund) and Dept. of Biomedical Engineering, Lund University, Lund, Sweden (2)
Division of Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden (2)
Immunology programme, The Babraham Institute, Cambridge, UK (2)
Zhejiang Academy of Agricultural Sciences (2)
College of Chemistry and Molecular Engineering, Peking University, Beijing, China. (2)
Center for Immunity and Immunotherapies, Seattle Children's Research Institute. Department of Pediatrics, University of Washington. Seattle, WA USA (2)
Dept. of Biological Chemistry The Institute of Life Science The Hebrew University of Jerusalem Jerusalem 91904, Israel (2)
Institute of Animal Husbandry and Veterinary Sciences, Zhejiang Academy of Agricultural Sciences (2)
Instituto de Parasitología y Biomedicina "López - Neyra", CSIC Departamento de Biología Celular e Inmunología Parque Tecnológico de Ciencias de la Salud, Avda. del Conocimiento, s/n 18016, Granada-Spain (2)
International Institute of Molecular and Cell Biology in Warsaw, Poland (2)
Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland (2)
Laboratory of Biotechnology of Reproduction, Institute for Animal Science and Technology (ICTA), Universitat Politècnica de València, 46022 Valencia, Spain (2)
Faculty of Life Sciences, University of Dundee (2)

Keyword

Immune Insufficiency (1)
Immunocompromised Host (1)
Traditional Chinese medicine (1)
Vaccines (1)

IsPrivate

False (13)

Model Flag

Non Kinetic (3)
Non Miriam (1)

Submitter Keywords

Immuno-oncology (1)

Classification

bacteria (37)
viruses (11)
protozoa (5)
fungi (1)

Modification

Not available (3)
42.010565 (2)
15.994915 (2)
N6 (2)
57.021464 (2)
42.04695 (1)
229.162932 (1)
28.0313 (1)
144.102062 (1)
0.984016 (1)
79.966331 (1)
-18.010565 (1)
-17.026549 (1)
N6-dimethyl-L-lysine (1)

Study type

Transcription profiling by array (1335)
RNA-seq of coding RNA (277)
ChIP-seq (112)
RNA-seq of coding RNA from single cells (62)
Comparative genomic hybridization by array (39)
Unknown experiment type (32)
Methylation profiling by array (29)
Methylation profiling by high throughput sequencing (27)
RNA-seq of non coding RNA (20)
Other (17)
Animal - High-throughput sequencing (14)
ATAC-seq (12)
RNA-seq of total RNA (12)
Genotyping by array (10)
Transcription profiling by RT-PCR (8)
DNA-seq (8)
MicroRNA profiling by array (7)
ChIP-chip by tiling array (5)
Transcription profiling by SAGE (4)
Differential (4)
Human - High-throughput sequencing (4)
ChIP-chip by array (4)
Proteomic profiling by array (4)
Human - One-color microarray (3)
Animal - One-color microarray (2)
Cell line - One-color microarray (2)
High-throughput sequencing (2)
Transcription profiling by tiling array (2)
Antigen profiling (2)
MicroRNA profiling by high throughput sequencing (2)

Release Date

2022 (1453)
2021 (1241)
2023 (1234)
2025 (1151)
2020 (1035)
2024 (994)
2019 (787)
2018 (758)
2016 (734)
2014 (727)
2015 (716)
2017 (708)
2013 (558)
2012 (513)
2010 (395)
2011 (384)
2009 (226)
2008 (218)
2026 (160)
2007 (110)
2006 (87)
2005 (69)
2004 (34)
2003 (33)
2002 (31)
2001 (31)
1998 (26)
2000 (21)
1999 (21)
1997 (12)

Location

China (16)
United States (2)
Australia (1)

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Disruption of the Brain-Spleen Axis Impairs Monocyte-Microglia Communication and Accelerates Disease Progression in a Mouse Model of Amyloidosis

Alzheimer’s disease (AD) is characterized by a prolonged asymptomatic phase before cognitive decline emerges, yet the mechanisms driving symptom onset remain unclear. Here, we hypothesized that the transition from asymptomatic to symptomatic disease is linked to dysfunction of brain–immune communica...

2026-06-01 | MTBLS14615 | MetaboLights

Exogenous L-Alanine promotes phagocytosis multidrug-resistant bacterial pathogens (V. parahaemolyticus-infected spleen metabolomics)

Multidrug-resistant bacteria present a major threat to public health. Therefore, new drugs or approaches are urgently needed to manage and mitigate this threat. Here, we screen the molecular candidates that allow the survival of mice upon Vibrio parahaemolyticus infection by integrated p...

2024-09-26 | MTBLS7996 | MetaboLights

Rat spleen proteomics profiling

Sample preparation optimisation for extracting in a quantitative manner proteins from rat spleen

ORGANISM(S): Rattus norvegicus (Rat)

2016-07-04 | PXD003520 | Pride