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MetabolomicsComprehensive Metabolic Profiling of Age-Related Mitochondrial Dysfunction in the High-Fat-Fed ob/ob Mouse Heart
The ectopic deposition of fat is thought to lead to lipotoxicity and has been associated with mitochondrial dysfunction and diabetic cardiomyopathy. We have measured mitochondrial respiratory capacities in the hearts of ob/ob and wild-type mice on either a regular chow (RCD) or high-fat (HFD) diet a...
2015-11-17 | MTBLS173 | MetaboLights
TranscriptomicsMitochondrial contagion induced by Parkin deficiency in Drosophila hearts and its containment by suppressing mitofusin; germline Parkin knockout mouse hearts.
Dysfunctional Parkin-mediated mitophagic culling of senescent or damaged mitochondria is a major pathological process underlying Parkinson disease and a potential genetic mechanism of cardiomyopathy. Despite epidemiological associations between Parkinson disease and heart failure, the role of Parkin...
ORGANISM(S): Mus musculus 
2015-10-31 | E-GEOD-74517 | biostudies-arrayexpress
MetabolomicsMetabolomics of the interaction between PPAR-alpha and age in the PPAR-alpha-null mouse (NMR assay)
Regulation between the fed and fasted state in mammals is partially controlled by peroxisome proliferator activated receptor-alpha (PPAR-alpha). Expression of the receptor is high in liver, heart and skeletal muscle, but decreases with age. A combined 1H NMR spectroscopy and GC-MS metabolomic approa...
2018-10-11 | MTBLS261 | MetaboLights
MetabolomicsTen Mouse Organs Proteome and Metabolome Atlas from Adult to Aging

The complexity of the aging process, encompassing numerous organs and systems, poses a significant challenge in identifying and targeting key factors that drive age-related decline. The multi-organ synchronous molecular intricacies underlying natural aging remain elusive. Here we presented a data...

2025-08-29 | MTBLS10642 | MetaboLights
ProteomicsAge-Related Disruption of the Proteome and Acetylome in Mouse Hearts Correlates with Differential Loss of Function that is Attenuated by SS-31 and NMN
We analyzed the effects of aging on protein abundance and acetylation, as well as the ability of the mitochondrial-targeted drugs SS-31 and NMN to reverse age-related changes, in mouse hearts. Both drugs had a modest effect on restoring the abundance and acetylation of proteins that are lost with ag...
ORGANISM(S): Mus Musculus 
2022-08-02 | PXD027458 | panorama
TranscriptomicsMouse Dbh-/- vs. Dbh+/+ E10.5 hearts
Genomic microarray analysis of adrenergic-deficient (Dbh-/-) vs. wild-type control (Dbh+/+) mouse heart expression at embryonic day 10.5 (E10.5). Four Dbh-/- and four Dbh+/+ E10.5 hearts were isolated, and RNA was extracted from each for genomic microarray analysis using Affymetrix 430A 2.0 arrays. ...
ORGANISM(S): Mus musculus 
2012-11-06 | E-GEOD-33906 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse hearts from mutants lacking estrogen-related receptor alpha (ERRalpha), a nuclear receptor
Total RNA was isolated from 3 WT and 3 ERRalpha null hearts and independent hybridizations were performed using MOE430 2.0 microarrays. Expression profiling was conducted to determine changes in gene expression in hearts lacking ERRa. The expression of genes involved in heart and muscle development,...
ORGANISM(S): Mus musculus 
2007-11-10 | E-GEOD-7196 | biostudies-arrayexpress
TranscriptomicssnRNA-seq of whole hearts from adult BL6 mice
We used snRNA-seq to investigate an entire adult mammalian heart of BL6 mice. Whole hearts were harvested from 4 male mice (12 weeks) after cervical dislocation. The hearts were pooled and nuclei isolated using the Nuclei PURE Prep isolation kit (Sigma-Aldrich, Darmstadt, Germany) according to the m...
ORGANISM(S): Mus musculus 
2020-03-16 | E-MTAB-8848 | biostudies-arrayexpress
MetabolomicsMetabolomic profiling of mouse heart in a model of Cardiovascular-Kidney-Metabolic syndrome

Cardiovascular-kidney-metabolic (CKM) syndrome is a complex systemic disorder. In this study, we developed a urea-activated nanoparticle (T-PAAD NP) for targeted delivery of Empagliflozin to the renal S1 segment. Untargeted GC-MS-based metabolomics was performed to characterize metabolic reprogra...

2026-03-21 | MTBLS13991 | MetaboLights
TranscriptomicssnRNA-seq of whole hearts from adult fzt:DU mice
We used snRNA-seq to investigate for the first time an entire adult mammalian heart. To avoid potential aberrations due to inbreeding, we relied on an outbred mice strain (Fzt:DU) (Dietl, G.; Langhammer, M.; Renne, U. Model simulations for genetic random drift in the outbred strain Fzt:DU. Arch. Ani...
ORGANISM(S): Mus musculus 
2020-02-22 | E-MTAB-8751 | biostudies-arrayexpress
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