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Hepatitis B virus (HBV) core antigen (HBc) is a structural protein that forms the viral nucleocapsid and is involved in various steps of the viral replication cycle, but its role in the pathogenesis of HBV infection is still elusive. In this study, we generated a mouse monoclonal antibody against HB...
ORGANISM(S): Homo Sapiens (human) 
Effect of mouse hepatitis virus strain A59 replication on gene expression and mRNA stability in LR cells
ORGANISM(S): Mus musculus 
Small, non-coding RNAs control gene expression post-transcriptionally and play important roles in virus-host interactions. Within the liver, the microRNA (miRNA) miR-122 is essential for replication of hepatitis C virus (HCV), while repression of miR-148a by hepatitis B virus (HBV) may enhance tumor...
ORGANISM(S): Homo sapiens 
Chronic infections by hepatitis B virus (HBV) and hepatitis C virus (HCV) appear to be the most significant causes of hepatocellular carcinoma (HCC). Aberrant promoter methylation is known to be deeply involved in cancer, including HCC. In this study, we analyzed aberrant promoter methylation on gen...
ORGANISM(S): Homo sapiens 
Infection of cells with murine hepatitis virus strain A59 (MHV-A59) results in massive amounts of viral RNA within infected cells. When applying transcriptional profiling by means of microarray analysis, this could potentially cause problems since high amounts of viral RNA could in theory interfere ...
ORGANISM(S): Mus musculus 
Genome wide DNA methylation analysis using 20 human hepatocyte chimeric mice after hepatitis viral infection.
ORGANISM(S): Mus musculus 
Background/Aims: Ribavirin improves treatment response to pegylated-interferon (PEG-IFN) in chronic hepatitis C but the mechanism remains controversial. We studied correlates of response and mechanism of action of ribavirin in treatment of hepatitis C. Methods: 70 treatment-naïve patients were rand...
ORGANISM(S): Homo sapiens 
Background and Aims: Whether hepatitis B virus (HBV) could play a direct role in hepatocarcinogenesis remains uncertain. The 3' end nonsense mutations of HBV PreS/S gene have been found to encode transcriptional transactivation activity, suggesting these mutations may contribute to HBV-associated on...
ORGANISM(S): Mus musculus 
We perform genome wide methylation analysis using 33 clinical samples, which were obtained from patients who underwent surgical resection at the Aichi Cancer Center Hospital in accordance with institutional policies. The purpose of this experiment is revealing the methylation status affected by hepa...
ORGANISM(S): Homo sapiens 
Genome wide DNA methylation analysis usig two individual huh7.5.1 after HCV-JFH1 infection
ORGANISM(S): Homo sapiens 
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