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MetabolomicsGLS2KO vs WT mouse hepatocytes
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ORGANISM(S): Mus musculus 
ST001952 | MetabolomicsWorkbench
MetabolomicsResveratrol metabolism in HepG2 (human hepatocytes), HaCaT (human keratinocytes), and C2C12 (mouse myoblasts)
Resveratrol (RESV) is a plant polyphenol, which is thought to have beneficial metabolic effects in laboratory animals as well as in humans. Following oral administration, RESV is immediately catabolized, resulting in low bioavailability. This study compared RESV metabolites and their tissue distribu...
MTBLS127 | MetaboLights
MetabolomicsLipidomic analysis of lipid droplets from murine hepatocytes reveals distinct signatures for nutritional stress
Liver steatosis can be induced by fasting or high-fat diet. We investigated by lipidomic analysis whether such metabolic states are reflected in the lipidome of hepatocyte lipid droplets (LDs) from mice fed normal chow diet (FED), fasted (FAS), or fed a high-fat diet (HFD). LC-MS/MS at levels of lip...
2014-08-19 | MTBLS26 | MetaboLights
MetabolomicsThe impact of genetic stress by ATGL deficiency on the lipidome of lipid droplets from murine hepatocytes
We showed earlier that nutritional stress like starvation or high fat diet resulted in phenotypic changes in the lipidomes of hepatocyte lipid droplets (LDs), representative for the pathophysiological status of the mouse model. Here we extend our former study by adding genetic stress due to knock-ou...
2014-08-19 | MTBLS81 | MetaboLights
TranscriptomicsExpression data of hepatocytes isolated from chimeric mouse livers repopulated with human hepatocytes and from normal human livers
We generated chimeric mice with livers that were predominantly repopulated with human hepatocytes. Hepatocytes were isolated from the chimeric mouse livers and their gene expressions were compared with hepatocytes isolated from normal human livers . Cluster and principal components analyses showed t...
ORGANISM(S): Mus musculus 
2012-11-27 | E-GEOD-33846 | biostudies-arrayexpress
TranscriptomicsDissecting modes of action of non-genotoxic carcinogens in primary mouse hepatocytes.
Under REACH, the European Community Regulation on chemicals, the testing strategy for carcinogenicity is generally based on in vitro and in vivo genotoxicity assays. Given that non-genotoxic carcinogens are negative for genotoxicity, this class of carcinogens will not be detected. Therefore, alterna...
ORGANISM(S): Mus musculus 
2012-06-25 | E-GEOD-35058 | biostudies-arrayexpress
TranscriptomicsMolecular anatomy of gene expression responses in stressed hepatocytes
It is well-known that isolation and cultivation of primary hepatocytes causes major gene expression alterations. In the present genome-wide, time resolved study of cultivated human and mouse hepatocytes, we made the observation that expression changes in culture strongly resemble alterations in live...
ORGANISM(S): Mus musculus 
2016-09-28 | E-MTAB-4444 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human and mouse hepatocytes to perform a comparative analysis of gene regulation by the transcription factor PPARI?_mouse
Studies in mice have shown that PPARα is an important regulator of hepatic lipid metabolism and the acute phase response. However, little information is available on the role of PPARα in human liver. Here we set out to compare the function of PPARα in mouse and human hepatocytes via analysis of t...
ORGANISM(S): Mus musculus 
2009-09-25 | E-GEOD-17250 | biostudies-arrayexpress
TranscriptomicsBenzo[a]pyrene response in primary mouse hepatocytes
Gene expression changes to several concentrations of benzo[a]pyrene in primary hepatocytes of wildtype and Xpa-/-p53+/- mice
ORGANISM(S): Mus Musculus 
2011-08-11 | E-TABM-1139 | biostudies-arrayexpress
TranscriptomicsExpression data from human (h-) growth hormone-treated and untreated chimeric mouse liver repopulated with human hepatocytes
We generated h-hepatocyte chimeric mice with livers that were predominantly repopulated with h-hepatocytes in a h-growth hormone (GH)-deficient state. Using microarray profiles, comparison between h-hepatocytes from h-GH-treated and untreated mice identified 14 GH-up-regulated and four GH-down-regul...
ORGANISM(S): Mus musculus 
2011-01-25 | E-GEOD-26224 | biostudies-arrayexpress
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