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ProteomicsA low-input proteomic analysis of mouse maternal-to-zygotic transition
Maternal-to-zygotic transition (MZT) is a conserved and fundamental process during which the maternal environment of oocyte transits to the zygotic genome driven expression program, and terminally differentiated oocyte and sperm are reprogrammed to totipotency. It is initiated by maternal mRNAs and ...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-27 | PXD041023 | Pride
Zygotic genome activation Maternal-to-zygotic transition Low-input proteomic technology Mouse embryo Mouse oocyte 
ProteomicsUltrasensitive proteomics depicted an in-depth landscape for the very early stage of mouse maternal-to-zygotic transition
Maternal-to-zygotic transition (MZT) is a conserved and fundamental process during which the maternal environment of oocyte transits to the zygotic genome driven expression program, and terminally differentiated oocyte and sperm are reprogrammed to totipotency. Metaphase II (MII) oocytes and zygotes...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-23 | PXD041399 | Pride
Mouse maternal-to-zygotic transition One-cell embryo Metaphase ii (mii) oocyte Ultrasensitive proteome technology 
GenomicsProfiling and functional characterization of maternal mRNA translation in mouse maternal-to-zygotic transition
Profiling and functional characterization of maternal mRNA translation in mouse maternal-to-zygotic transition
PRJNA717246 | ENA
GenomicsRNA-Seq profiling of Sirt1 deficient mouse oocytes to investigate Sirt1 role in maternal-zygotic transition
RNA-Seq profiling of Sirt1 deficient mouse oocytes to investigate Sirt1 role in maternal-zygotic transition
PRJEB67751 | ENA
TranscriptomicsRNA-Seq profiling of Sirt1 deficient mouse oocytes to investigate Sirt1 role in maternal-zygotic transition
Sirtuin-1 (Sirt1), a NAD+-dependent histone deacetylase, exhibits several properties of a versatile driver of maternal-zygotic transition, due to its epigenetic and non-epigenetic substrates. The study was aimed at the dynamics of Sirt1 in early embryos and the contribution to maternal-zygotic trans...
ORGANISM(S): Mus musculus 
2024-07-06 | E-MTAB-13483 | biostudies-arrayexpress
GenomicsThe degradation of maternal RNA-binding protein 4E-T regulates translational activation to ensure maternal-to-zygotic transition in mouse embryos
The degradation of maternal RNA-binding protein 4E-T regulates translational activation to ensure maternal-to-zygotic transition in mouse embryos
PRJNA1393031 | ENA
UnknownProfiling and functional characterization of maternal mRNA translation during mouse maternal-to-zygotic transition.
Not available
S-EPMC8809684 | biostudies-literature
TranscriptomicsProfiling and functional characterization of maternal mRNA translation in mouse maternal-to-zygotic transition
Translational regulation plays an important role in gene expression and function. Although the transcriptional dynamics of mouse pre-implantation embryos has been well characterized, the global mRNA translation landscape and the master regulators of zygotic genome activation (ZGA) remain unknown. He...
ORGANISM(S): Mus musculus 
2021-11-28 | GSE169632 | GEO
UnknownBroad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.
Not available
S-EPMC6283663 | biostudies-literature
GenomicsUnique Broad Histone Lysine 4 Methylation Domains in Mouse Oocytes and Dynamic Regulation during Maternal to Zygotic Transition
Unique Broad Histone Lysine 4 Methylation Domains in Mouse Oocytes and Dynamic Regulation during Maternal to Zygotic Transition
PRJNA295056 | ENA
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