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TranscriptomicsClinical relevance of SKP2 alterations in metastatic melanoma
Melanoma cell lines were genotyped to evaluate copy number differences between nodular melanoma (NM) and superficial spreading melanoma (SSM). Cell lines were also evaluated for copy number alterations in the SKP2/p27 axis. Affymetrix SNP arrays were performed according to manufacturer's instruction...
ORGANISM(S): Homo sapiens 
2010-10-21 | E-GEOD-22305 | biostudies-arrayexpress
TranscriptomicsAffymetrix copy number data for melanoma cell line mapping
We searched for putative phenotypic and genotypic differences between primary lesions and melanoma metastasis. Therefore, we investigated melanoma cells derived either from the primary tumor or from lymph node metastasis of the same individual patient. In vitro studies revealed high migratory and an...
ORGANISM(S): Homo sapiens 
2011-04-07 | E-GEOD-22461 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of Wnt-1 overexpressing melanoma
We aimed to analyze the effects of Wnt-1 overexpression on the mRNA expression profile of human melanoma in a mouse xenograft model and correlated the results with then presence or absence of lymphangiogenesis and metastasis. Affymetrix gene expression analysis revealed activation of canonical and n...
ORGANISM(S): Homo sapiens 
2012-06-04 | E-GEOD-26656 | biostudies-arrayexpress
TranscriptomicsGene expression data from melanoma cell lines and melanocyte controls
The two most common melanoma histopathologic subtypes, superficial spreading (SSM) and nodular melanoma (NM), are believed to represent sequential phases of linear progression from radial to vertical growth. Studies suggest, however, that SSM and NM are biologically distinct. We utilized an integrat...
ORGANISM(S): Homo sapiens 
2010-12-01 | E-GEOD-22301 | biostudies-arrayexpress
TranscriptomicsRNA seq of B16 mouse melanoma cell line upon knockdown of gene myg1
The aim of the experiment was to study the effect on RNA processing upon Myg1 knockdown in B16 mouse melanoma cell line. Using siRNAs, Myg1 was silenced and the total RNA was isolated from defined compartments such as Nucleus and Mitochondria. From these samples, RNA sequencing analysis was performe...
ORGANISM(S): Mus musculus 
2019-05-21 | E-MTAB-7240 | biostudies-arrayexpress
TranscriptomicsExpression analysis of zebrafish melanoma and skin from the mitf-BRAFV600E;p53-/- line
Investigation of expression differences between skin and melanomas from a transgenic BRAFV600E zebrafish model of melanoma The embryos described in this study are further analyzed in a manuscript submitted for publication by White, et al. A 15 chip study using RNA extracted from either WT zebrafish ...
ORGANISM(S): Danio rerio 
2011-03-30 | E-GEOD-24528 | biostudies-arrayexpress
MetabolomicsFecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial

Fecal microbiota transplantation (FMT) represents a potential strategy to overcome resistance to immune checkpoint inhibitors in patients with refractory melanoma; however, the role of FMT in first-line treatment settings has not been evaluated. We conducted a multicenter phase I trial combining ...

2025-02-27 | MTBLS711 | MetaboLights
TranscriptomicsIntegrative genomics identifies molecular alterations that differentiate superficial spreading and nodular melanoma
This SuperSeries is composed of the following subset Series: GSE22301: Gene expression data from melanoma cell lines and melanocyte controls GSE22305: Affymetrix SNP6.0 Array data for melanoma cell lines Refer to individual Series
ORGANISM(S): Homo sapiens 
2010-12-01 | E-GEOD-22306 | biostudies-arrayexpress
TranscriptomicsIn vitro characterization of stem-like cancer cells in melanoma cell lines
Nine heterogeneous melanoma cell lines including D10 and WM115 were studied for cancer stem cell characteristics in vitro. D10 cell line was the only cell line expressing the cancer stem cell marker CD133. Thus, gene expression profiling on CD133+ and CD133- D10 cells was carried out using Affymetri...
ORGANISM(S): Homo sapiens 
2013-01-17 | E-MEXP-3542 | biostudies-arrayexpress
ProteomicsImmunoprecipitaiton of Rab27a from mouse melanoma cells
To identify the co-immunoprecipitating proteins of Rab27a following Rab27a pull down of B16-F1 mouse melanoma cells infected with adenovirus expressing GFP-hsSPIRE1.
ORGANISM(S): Mus musculus (Mouse) 
2020-05-15 | PXD018083 | Pride
Lc-msms Rab27a Mouse melanoma cell line 
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