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MetabolomicsMulti-omic responses of mouse liver and skeletal muscle to chronic alcohol drinking

The aim of this study was to define and compare the molecular blueprints of chronic alcohol use in the liver and skeletal muscle using an established pre-clinical mouse model.

2025-12-11 | MTBLS12616 | MetaboLights
MetabolomicsLC-MS based untargeted metabolomics of muscle in GMPPB mutant mice
Muscle tissues from GMPPB mutant mouse model and control mice were collected, untargeted metabolomics was performed via LC-MS (positive/negative HILIC), differential metabolites were identified to explore the mechanismof GMPPB in muscular dystrophy.
2026-02-03 | MTBLS10214 | MetaboLights
MetabolomicsClenbuterol exerts antidiabetic activity through metabolic reprogramming of skeletal muscle cells
Activation of the sympathetic nervous system causes pronounced metabolic changes that are mediated by multiple adrenergic receptor subtypes. Systemic treatment with β2-adrenergic receptor agonists results in multiple beneficial metabolic effects, including improved glucose homeostasis. To...
2022-08-26 | MTBLS467 | MetaboLights
MetabolomicsSerine synthesis pathway enzyme PHGDH is critical for muscle cell biomass, anabolic metabolism and mTORC1 signaling

Cells use glycolytic intermediates for anabolism e.g., via the serine synthesis and pentose phosphate pathways. However, we still understand poorly how these metabolic pathways contribute to skeletal muscle cell biomass generation. The first aim of this study was therefore to identify enzymes tha...

2025-03-21 | MTBLS8854 | MetaboLights
MetabolomicsExercise-Associated Microbial Metabolites Prevent Skeletal Muscle Atrophy in Adult Mice
We previously reported that skeletal muscle adaptation to regular exercise requires a healthy gut microbiome, contributing to growing evidence that some exercise benefits are mediated by microbiome-derived metabolites. Here, to identify such exercise-associated microbial metabolites, we transfer cec...
2026-05-27 | MTBLS14386 | MetaboLights
MetabolomicsPEROXISOMAL-MITOCHONDRIAL INTERPLAY ALTERATIONS IN SKELETAL MUSCLE RESULT IN EARLY-ONSET SARCOPENIA

Adjustments in muscle mass and metabolic demand are crucial for regulating whole-body metabolism, locomotion, eating, and respiration. Therefore, skeletal muscle is a central influencer of several human diseases. Muscle dysfunction correlates with the onset and progression of several metabolic di...

2025-09-15 | MTBLS12833 | MetaboLights
MetabolomicsPhotosynthetic bioenergetic-redox restoration rejuvenates the aged muscle regenerative niche

Aging impairs muscle regeneration, but the key constraint remains unclear. Aged injured muscle fails to restore mitochondrial respiration, membrane potential, ATP/NADPH balance and redox control, forming a bioenergetic-redox bottleneck. To target this, we engineered CM-NTU-Ce, a C2C12 membrane-co...

2026-08-13 | MTBLS15312 | MetaboLights
MetabolomicsMitochondrial NAD+ Deficiency in Vascular Smooth Muscle Impairs Collagen III Turnover to Trigger Aortic Disease

Aortic disease poses a significant mortality risk in adults, yet many of its underlying factors remain undiscovered. In this study, we identify mitochondrial NAD⁺ deficiency as a causal factor. Metabolomics analysis of 73 surgical aortic specimens revealed impaired NAD⁺ salvage and mitochondrial ...

2024-12-04 | MTBLS8062 | MetaboLights
MetabolomicsSemaglutide targets muscle mitochondria to regulate osteoarthritis

Metabolic and inflammatory diseases often coexist, and become important challenges facing global health, and obesity has shown to be a susceptibility factor for osteoarthritis (OA). As a metabolic regulatory drug for lowering blood sugar and body weight, semaglutide has shown additional therapeut...

2026-05-06 | MTBLS14059 | MetaboLights
MetabolomicsMetabolomics of the interaction between PPAR-alpha and age in the PPAR-alpha-null mouse (NMR assay)
Regulation between the fed and fasted state in mammals is partially controlled by peroxisome proliferator activated receptor-alpha (PPAR-alpha). Expression of the receptor is high in liver, heart and skeletal muscle, but decreases with age. A combined 1H NMR spectroscopy and GC-MS metabolomic approa...
2018-10-11 | MTBLS261 | MetaboLights
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