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ProteomicsProteomic quantification of native and ECM-enriched mouse ovaries reveals an age-dependent fibro-inflammatory signature
The ovarian microenvironment becomes fibrotic and stiff with age due in part to increased stromal collagen and decreased hyaluronan. However, the extracellular matrix (ECM) is a complex network of hundreds of proteins, glycoproteins and glycans which are highly tissue specific and undergo pronounced...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-04-24 | MSV000091790 | MassIVE
TranscriptomicsTranscription profiling of mouse Foxo3 mutant ovaries vs. wild types to discover and classify ovarian fertility factors.
Female infertility syndromes are among the most prevalent chronic health disorders in women, but their molecular basis remains unknown because of the complexity of oogenesis and uncertainty regarding the number and identity of ovarian factors controlling the assembly, preservation, and maturation of...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-8249 | biostudies-arrayexpress
TranscriptomicsLim Homeobox Gene, LHX8, Is Essential for Mouse Oocyte Differentiation and Survival
Lhx8 is a member of the LIM-homeobox transcription factor family and preferentially expressed in oocytes and germ cells within the mouse ovary. We discovered that Lhx8 knockout females lose oocytes within 7 days after birth. At the time of birth, histological examination shows that Lhx8 deficient (L...
ORGANISM(S): Mus musculus 
2008-06-25 | E-GEOD-11897 | biostudies-arrayexpress
TranscriptomicsEffects of Aging and Calorie Restriction on the Global Gene Expression Profiles of Mouse Testis and Ovary
AGEMAP is an initiative of the National Institute on Aging (NIA) designed to study the aging process on mice with Caloric Restriction (CR) versus Ad Libitum (AL) diet. The aim of the AGEMAP project is to provide a valuable source of information about genetic influences involved in aging of the major...
ORGANISM(S): Mus musculus 
2010-05-26 | E-GEOD-7502 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat embryonic testis and ovaries of age E13, E14, or E16, and E13 testis to identify candidate genes in gonadal development
Embryonic day 13 (E13), E14, and E16 rat testes and ovaries were used for microarray analysis, as well as E13 testis organ cultures that undergo testis morphogenesis and develop seminiferous cords in vitro. A list of 109 genes resulted from a selective analysis for genes present in male gonadal deve...
ORGANISM(S): Rattus norvegicus 
2008-04-07 | E-GEOD-10558 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse ovaries lacking Foxl2, Wnt4 or Kit and wild type ovaries and testes
Comparison of Foxl2-null ovaries to wildtype ovaries, ovaries lacking Wnt4 or Kit, or testes, throughout mouse development. The goal of this study was to identify early Foxl2 target genes as well as other ovarian, anti-testis genes that may act independently of Foxl2. Experiment Overall Design: We s...
ORGANISM(S): Mus musculus 
2009-07-05 | E-GEOD-12905 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse ovaries from FORKO mutants animals
To understand consequences of loss of FSH receptor, we used genetically altered mouse mutants with deletion of this receptor. Follitropin Receptor Knockout (FORKO) mice present various developmental and age-dependent abnormalities such as infertility, senescence and increased tumor incidences in add...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-4323 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse ovaries from newborns
Microarray analysis of normal newborn ovarian transcript levels, for use in comparison to array based studies of differential expression in mouse knockout models. Experiment Overall Design: Newborn ovaries were pooled separately from wild type animals and total RNA isolated using RNeasy mini kit (Q...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7776 | biostudies-arrayexpress
ProteomicsMass spectrometry data analyzing the DEPs of ovaries from control and Adcy3 KO mice
We collected ovaries from control and KO female mice. We then conducted proteomics analysis to identify the differentially expressed proteins (DEPs) in the ovary and the essential components that result in female reproductive aging upon Adcy3 deletion.
ORGANISM(S): Mus musculus (Mouse) 
2024-06-25 | PXD053066 | Pride
Adcy3 Deps Mass spectrometry Ovaries 
TranscriptomicsTranscriptional profiling by array of ovaries from aged mice
We transcriptionally profiled ovaries harvested from young and middle-aged outbred CD1 mice to elucidate mechanisms and identify novel markers of ovarian aging.
ORGANISM(S): Mus musculus 
2018-12-15 | E-MTAB-7493 | biostudies-arrayexpress
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