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MetabolomicsGABA regulates IL-1β production in macrophages
Neurotransmitters have been well-documented to determine immune cell fates; however, whether and how γ-amino butyric acid (GABA) shapes the function of innate immune cells is still obscure. Here, we demonstrated that GABA orchestrates macrophage maturation and inflammation. GABA treatment during mac...
2023-01-31 | MTBLS6337 | MetaboLights
TranscriptomicsTranscriptome changes in IL-10 treated peritoneal macrophages
To try to identify the mechanism of STAT3s indirect action we have used a genomic approach to map the binding sites of STAT3 within the genome and also used RNA-seq technology to map the changes in RNA expression and transcript isoform abundance in response to IL-10. Examination of transcriptome cha...
ORGANISM(S): Mus musculus 
2012-02-13 | E-GEOD-31530 | biostudies-arrayexpress
GenomicsGenome-wide analysis of STAT3-binding and gene expression changes in peritoneal macrophages upon interleukin-10 stimulation
This SuperSeries is composed of the following subset Series: GSE31529: Genome-wide binding of STAT3 in peritoneal macrophages GSE31530: Transcriptome changes in IL-10 treated peritoneal macrophages Refer to individual Series
ORGANISM(S): Mus musculus 
2012-02-13 | E-GEOD-31531 | biostudies-arrayexpress
GenomicsGenome-wide binding of STAT3 in peritoneal macrophages
To try to identify the mechanism of STAT3’s indirect action we have used a genomic approach to map the binding sites of STAT3 within the genome and also used RNA-seq technology to map the changes in RNA expression and transcript isoforms in response to IL-10. Examination of STAT3 binding by ChIP-s...
ORGANISM(S): Mus musculus 
2012-02-13 | E-GEOD-31529 | biostudies-arrayexpress
TranscriptomicsPeritoneal macrophage heterogeneity is associated with different peritoneal dialysis outcomes
Transcriptome analysis of two population of peritoneal mononuclear phagocytes (CD14+ macrophages and CD1c+ dendritic cells) in peritoneal dialysis effluent from stable (infection-free) peritoneal dialysis patients.
ORGANISM(S): Homo sapiens 
2017-01-23 | E-MTAB-5439 | biostudies-arrayexpress
TranscriptomicsExpression data from isolated peritoneal macrophages treated with Histidine-rich glycoprotein
Histidine-rich glycoprotein (HRG) is a 75 kDa heparin-binding plasma protein which has been implicated in regulation of tumor angiogenesis and growth. To exert some of its biological functions, HRG acts on macrophages.This study was performed to assess changes in gene expression in peritoneal macrop...
ORGANISM(S): Mus musculus 
2011-12-06 | E-GEOD-34164 | biostudies-arrayexpress
TranscriptomicsCircadian transcriptional profiling of peritoneal macrophages
In the immune system various parameters and immune functions are controlled by the circadian system. To investigate molecular mechanisms that link the circadian clock and the immune system we analyzed the transcriptom of peritoneal macrophages from mice collected in a time course for two consecutive...
ORGANISM(S): Mus musculus 
2010-11-24 | E-GEOD-25585 | biostudies-arrayexpress
TranscriptomicsExpression data from peritoneal macrophages stimulated with trehalose-6,6'-dimycolate (TDM)
Macrophage-inducible C-type lectin (Mincle, Clec4e) is a pathogen sensor that recognizes pathogenic fungi and Mycobactrium tuberculosis. We perfomed microarray analysis using peritoneal macrophages stimulated with TDM, a mycobacterial cell wall glycolipid that is known to be a Mincle ligand. Many ch...
ORGANISM(S): Mus musculus 
2013-11-14 | E-GEOD-52338 | biostudies-arrayexpress
MetabolomicsTGF-β uncouples glycolysis and inflammation in macrophages and controls the survival during sepsis

The mechanisms by which macrophage metabolism is regulated and the effects of metabolism on diseases remain largely unknown. We show here that TGF-β regulates the glycolysis of macrophages independently of inflammatory cytokine production, and thus affects the survival in experimental sepsis. Spe...

2023-02-17 | MTBLS6886 | MetaboLights
TranscriptomicsTranscription profiling of mouse peritoneal macrophages treated with cholesterol
Peritoneal macrophages were extracted from 60 mice and then plated on tissue culture plates for treatment
ORGANISM(S): Mus musculus 
2005-01-01 | E-TIGR-119 | biostudies-arrayexpress
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