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ProteomicsDysferlin deficient mice proteomics
Investigation of age-dependent changes in the proteomic profile of Dysferlin-deficient mouse skeletal muscle relative to healthy muscle.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-01-04 | MSV000088639 | MassIVE
ProteomicsDeep muscle proteome - Deep skeletal muscle proteome. Triceps muscle from C57BL6 mouse and C2C12 myotubes were measure by LC-MS.
Deep skeletal muscle proteome. Triceps muscle from C57BL6 mouse and C2C12 myotubes were measure by LC-MS.
ORGANISM(S): Mus musculus (Mouse) 
2015-04-08 | PXD000288 | Pride
Skeletal muscle C2c12 myotubes 
ProteomicsSkeletal Muscle TFEB Signaling Promotes Central Nervous System Function and Reduces Neuroinflammation during Aging and Neurodegenerative Disease
Skeletal muscle has recently arisen as a novel regulator of Central Nervous System (CNS) function and aging, secreting bioactive molecules known as myokines with metabolism-modifying functions in targeted tissues, including the CNS. Here we report the generation of a novel transgenic mouse with enha...
ORGANISM(S): Mus Musculus 
2023-12-06 | PXD045241 | panorama
ProteomicsGadd45a Promotes Skeletal Muscle Atrophy by Forming a Complex with the Protein Kinase MEKK4
Skeletal muscle atrophy is a serious and highly prevalent condition that remains poorly understood at the molecular level. Previous work found that skeletal muscle atrophy involves an increase in skeletal muscle Gadd45a expression, which is necessary and sufficient for skeletal muscle fiber atrophy...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2016-05-17 | MSV000079730 | MassIVE
ProteomicsKH_dKO: Simultaneous loss of skeletal muscle myosin heavy chain IIx and IIb causes severe hypoplasia of skeletal muscles in young mice
Simultaneous loss of skeletal muscle myosin heavy chain IIx and IIb causes severe hypoplasia of skeletal muscles in young mice
ORGANISM(S): Mus Musculus (mouse) 
2022-11-28 | PXD032244 | JPOST Repository
ProteomicsProtein changes induced by UBA1 knockdown in Drosophila and mouse skeletal muscle.
Protein changes induced by UBA1 knockdown in Drosophila and mouse skeletal muscle.
ORGANISM(S): Mus musculus (Mouse) Drosophila melanogaster (Fruit fly) 
2026-08-13 | PXD067470 | Pride
Uba1  skeletal muscle  ubiquitination  proteostasis  mouse  drosophila. 
ProteomicsProteomics analysis of skeletal muscle from leptin-deficient ob/ob mice reveals adaptive remodeling of metabolic characteristics and fiber type composition
Skeletal muscle insulin resistance, an early metabolic defect in the pathogenesis of type 2 diabetes, may be a cause or consequence of altered protein expressions profiles. Proteomics technology offers enormous promise to investigate molecular mechanisms underlying pathologies, however, the analysis...
ORGANISM(S): Mus musculus (Mouse) 
2018-01-26 | PXD007697 | Pride
Mouse skeletal muscle Obesity C2c12 muscle cells Lcmsms Diabetes 
ProteomicsPlasminogen deficiency exacerbates skeletal muscle loss during mechanical unloading in developing mice
This project is “Medical proteome analysis of osteoporosis- and bone mass-related proteins using the Kibo Japanese Experiment Module of International Space Station (ISS)”. Applying proteomic technologies, this research aims to identify proteins involved in spaceflight-induced deterioration of muscul...
ORGANISM(S): Mus Musculus (mouse) 
2024-02-01 | PXD041806 | JPOST Repository
ProteomicsDefects in sarcolemma repair and skeletal muscle function after injury in a mouse model of Niemann-Pick type A/B disease
Background: Niemann-Pick disease type A (NPDA), a disease caused by mutations in acid sphingomyelinase (ASM), involves severe neurodegeneration and early death. Intracellular lipid accumulation and plasma membrane alterations are implicated in the pathology. ASM is also linked to the mechanism of pl...
ORGANISM(S): Mus musculus (Mouse) 
2023-06-28 | PXD019356 | Pride
Mouse Injury/repair Skeletal muscle 
ProteomicsNAD Depletion in Skeletal Muscle does not Compromise Muscle Function or Accelerate Aging
NAD is a ubiquitous electron carrier essential for energy metabolism and the post translational modification of numerous regulatory proteins. Perturbation of NAD metabolism is considered detrimental to health, with NAD depletion commonly thought to promote aging. However, the extent to which cellula...
ORGANISM(S): Mus musculus (Mouse) 
2025-04-23 | PXD061221 | Pride
Nad metabolism  nampt  skeletal muscle  aging  exercise  mitochondrial supercomplexes 
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